Neoplasia Practice Questions

Q: Gene for Wilm's tumor is located on which chromosome?

Chromosome 11. **Explanation:** **Correct Option: C (Chromosome 11)** Wilms tumor (Nephroblastoma) is the most common primary renal tumor of childhood. Its pathogenesis is closely linked to the **WT1 (Wilms Tumor 1) gene**, which is located on **Chromosome 11p13** [1]. This gene is essential for normal renal and gonadal development. Mutations or deletions in this region lead to the development of Wilms tumor, often as part of syndromic presentations like WAGR syndrome [1]. Additionally, the **WT2 gene** (associated with Beckwith-Wiedemann syndrome) is located on the same chromosome at **11p15.5**. **Incorrect Options:** * **Option A (Chromosome 1):** While 1p deletions can occur as a secondary genetic hit in Wilms tumor (indicating a poorer prognosis), it is not the primary locus for the Wilms tumor gene. * **Option B (Chromosome 10):** This is the location of the **RET proto-oncogene** (associated with MEN 2A, 2B, and Medullary Thyroid Carcinoma) and the **PTEN gene** (Cowden syndrome). * **Option D (Chromosome 12):** This chromosome is associated with mutations in **KRAS** and is often involved in liposarcomas (MDM2 amplification). **High-Yield Clinical Pearls for NEET-PG:** 1. **WAGR Syndrome:** Wilms tumor, Aniridia, Genitourinary anomalies, and mental Retardation (linked to 11p13 deletion) [1]. 2. **Denys-Drash Syndrome:** Wilms tumor, early-onset nephropathy, and male pseudohermaphroditism (WT1 mutation). 3. **Beckwith-Wiedemann Syndrome (BWS):** Characterized by macroglossia, organomegaly, and hemihypertrophy; linked to the WT2 locus (11p15.5). 4. **Triphasic Morphology:** On histology, Wilms tumor typically shows three components: blastemal, stromal, and epithelial cells. **References:** [1] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. Diseases of Infancy and Childhood, pp. 487-488.

Question 1

Which of the following is NOT a tissue or tumor-specific tumor marker?

Accepted Answer

LDH

Answer

PSA

Answer

Calcitonin

Answer

Catecholamines

Question 2

Which of the following statements is NOT true regarding epithelial-mesenchymal transition (EMT)?

Accepted Answer

It involves the downregulation of E-cadherin expression.

Answer

It is controlled by the transcription factors SNAIL and TWIST.

Answer

It is integral to the metastasis of carcinomas.

Answer

Homotypic intercellular adhesion is lost during the process.

Question 3

Loss of heterozygosity is associated with which of the following conditions?

Accepted Answer

Retinoblastoma

Answer

Acute myeloid leukemia

Answer

Acute lymphoblastic leukemia

Answer

Acute promyelocytic leukemia

Question 4

Gene for Wilm's tumor is located on which chromosome?

Accepted Answer

Chromosome 11

Answer

Chromosome 1

Answer

Chromosome 10

Answer

Chromosome 12

Question 5

Which of the following epithelial changes commonly signifies a precancerous condition?

Accepted Answer

Dyskeratosis

Answer

Hyperkeratosis

Answer

Parakeratosis

Answer

Acanthosis

Question 6

Which of the following is NOT a tumor associated with an infectious organism?

Accepted Answer

Non-small cell lung carcinoma

Answer

Hepatocellular carcinoma

Answer

Gastric carcinoma

Answer

Nasopharyngeal carcinoma

Question 7

Chimney sweepers' cancer is also known as:

Accepted Answer

Carcinoma of the scrotum

Answer

Carcinoma of the urinary bladder

Answer

Carcinoma of the testis

Answer

Carcinoma of the penis

Question 8

A 25-year-old man presents with bilateral gynecomastia and multiple metastatic tumor nodules in both lung fields. What is the most likely primary site of the cancer?

Accepted Answer

Testicle

Answer

Bone marrow

Answer

Kidney

Answer

Islets cells of the pancreas

Question 9

The tumor suppressor gene p53 induces cell cycle arrest at which phase?

Accepted Answer

G1-S phase

Answer

G2-M phase

Answer

S-G2 phase

Answer

G0 phase

Question 10

All of the following are involved in the tumor metastasis cascade except?

Accepted Answer

Tyrosine kinase

Answer

Fibronectin

Answer

e-cadherin

Answer

Type IV collagenase

Neoplasia — MCQs

Neoplasia — MCQs

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