Carcinogenesis and Carcinogens Practice Questions

Question 1

Gastric carcinoma is associated with all of the following EXCEPT:

Accepted Answer

Activation of RAS

Answer

Over expression of C-met

Answer

Inactivation of p53

Answer

Over expression of C-erb

Question 2

What is a potential outcome of the integration of a viral genome into a host cell chromosome?

Accepted Answer

All of the options

Answer

Altered growth

Answer

Malignancy

Answer

Latency

Question 3

Sun damage causes malignant transformation of the skin by:

Accepted Answer

Induction of pyrimidine dimers

Answer

Direct DNA damage

Answer

Free radical formation

Answer

Mutation of p53 due to UV exposure

Question 4

Field carcinogenesis theory is commonly seen in

Accepted Answer

Head and neck cancer

Answer

Cervical cancer

Answer

Prostate cancer

Answer

Breast cancer

Question 5

Which of the following is not a tumor suppressor gene?

Accepted Answer

HER2

Answer

p53

Answer

RB

Answer

BRCA1

Question 6

Radiation causes cell death by:

Accepted Answer

Ionization

Answer

Charring of nucleoproteins

Answer

Disruption of cytosol

Answer

Destroying their mitochondria

Question 7

Which of the following is not considered an occupational cancer?

Accepted Answer

Breast

Answer

Lung

Answer

Liver

Answer

Bladder

Question 8

The strongest occupational risk factor for hematological carcinoma is

Accepted Answer

Benzene

Answer

Lithium

Answer

Radiation exposure

Answer

Cigarette smoke

Question 9

Which of the following is NOT a recognized cause of Urothelial Carcinomas?

Accepted Answer

Alcohol consumption

Answer

Industrial solvents

Answer

Exposure to thorotrast

Answer

Smoking

Question 10

In which type of lung carcinoma is the p53 mutation most commonly observed?

Accepted Answer

Squamous cell carcinoma (SCC)

Answer

Adenocarcinoma

Answer

Large cell carcinoma

Answer

Small cell carcinoma

Carcinogenesis and Carcinogens — MCQs

Carcinogenesis and Carcinogens — MCQs

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