Molecular Diagnosis of Infectious Diseases Practice Questions

Question 1

A healthcare worker develops fever, night sweats, and cough. Sputum shows acid-fast bacilli. What is the next diagnostic test?

Accepted Answer

NAAT for TB

Answer

Gram stain

Answer

Serology for TB

Answer

Sputum culture

Question 2

A sexually active adolescent presents with cervicitis. Which specimen collection method has the highest sensitivity for detecting N. gonorrhoeae?

Accepted Answer

Clinician-collected endocervical swab

Answer

First-catch urine

Answer

Cervical gram stain

Answer

Self-collected vaginal swab

Question 3

Which of the following statements about nucleic acid amplification tests (NAATs) for STIs is FALSE?

Accepted Answer

They are less sensitive than culture for rectal chlamydia

Answer

They can be used for test of cure after 3 weeks

Answer

They can detect dead organisms after treatment

Answer

They can be used for pharyngeal gonorrhea screening

Question 4

A patient with cough was sputum AFB negative but chest X-ray was suggestive of TB. What should be the next step according to RNTCP?

Accepted Answer

Nucleic acid amplification test

Answer

Tuberculin test

Answer

Line probe assay

Answer

Culture

Question 5

False regarding Alzheimer's disease (AD) is:

Accepted Answer

Extracellular inclusion (lesion) can occur in the absence of intracellular inclusions to make pathological diagnosis of AD

Answer

Number of neurofibrillary tangles is associated with the severity of dementia

Answer

Number of senile (neuritic) plaques correlates (increases) with age

Answer

Presence of tau protein suggest neurodegeneration

Question 6

Molecular genetic testing is used to detect all of the following except?

Accepted Answer

Translocation

Answer

Deletion

Answer

Amplification

Answer

Point mutation

Question 7

Molecular genetic testing is used to detect all of the following except?

Accepted Answer

Translocation

Answer

Point mutation

Answer

Amplification

Answer

Deletion

Question 8

Dent's disease is characterized by all except:

Accepted Answer

Defect in limb of Loop of Henle

Answer

Nephrolithiasis

Answer

Males are affected

Answer

Chloride channel defect

Question 9

A patient with native aortic valve disease presents with right hemiparesis. What is the most appropriate management to prevent further strokes?

Accepted Answer

Anticoagulant only

Answer

Both antiplatelet and anticoagulant

Answer

One dose of low molecular weight heparin sub-cutaneously followed by dual antiplatelet therapy

Answer

Antiplatelet only

Question 10

Definitive diagnosis of Hirschsprung's disease is done by?

Accepted Answer

Rectal Biopsy

Answer

Rectal Manometry

Answer

Barium enema

Answer

Enteroclysis

Molecular Diagnosis of Infectious Diseases — MCQs

Molecular Diagnosis of Infectious Diseases — MCQs

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