Innate Immunity Practice Questions

Question 1

Which cytokine activates macrophages?

Accepted Answer

IFN-γ

Answer

Leukotriene B4

Answer

IL-8

Answer

PAF

Question 2

Most effective bactericidal system within phagocytes is-

Accepted Answer

Reactive oxygen metabolite mediated

Answer

Cationic basic protein mediated

Answer

Lysozyme mediated

Answer

Lactoferrin mediated

Question 3

Which is NOT a feature of chronic inflammation?

Accepted Answer

Neutrophil predominance

Answer

Mononuclear cells

Answer

Fibrosis

Answer

Granulation tissue

Question 4

Which of the following is least associated with the mediation of inflammation?

Accepted Answer

IFN

Answer

Prostaglandins/Interleukins

Answer

Myeloperoxidase

Answer

TNF

Question 5

All of the following are pattern recognition receptors for extracellular or ingested microbes, except:

Accepted Answer

Killer-cell immunoglobulin receptors (KIRs) - Recognize MHC class I molecules on host cells.

Answer

Toll-like receptors (TLRs) - Detect pathogen-associated molecular patterns (PAMPs).

Answer

NOD-like receptors (NLRs) - Intracellular sensors for microbial components.

Answer

C-type lectin receptors (CLRs) - Recognize carbohydrate structures on microbes.

Question 6

Virus-infected cells are killed by

Accepted Answer

Cytotoxic T lymphocytes (CTLs)

Answer

Natural killer (NK) cells

Answer

Macrophages

Answer

Neutrophils

Question 7

In which type of graft rejection is prior immunosuppression NOT helpful in prevention?

Accepted Answer

Hyperacute rejection

Answer

Chronic rejection

Answer

Acute rejection

Answer

Graft-versus-host disease

Question 8

Which of the following best denotes classical complement pathway activation in immune inflammatory conditions?

Accepted Answer

C2, C4 and C3 decreased

Answer

C2 and C4 normal, C3 is decreased

Answer

C3 normal and C2, C4 decreased

Answer

C2, C4, C3 all are elevated

Question 9

In chronic allergy, which immunoglobulin is predominantly elevated?

Accepted Answer

Ig E

Answer

Ig A

Answer

Ig M

Answer

Ig G

Question 10

Which of the following is the MOST COMMON cause of acute hypocomplementemia in children following an infection?

Accepted Answer

PSGN

Answer

Membranous GN

Answer

Focal Segmental Glomerulosclerosis (FSGS)

Answer

Membranoproliferative GN (MPGN)

Innate Immunity — MCQs

Innate Immunity — MCQs

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