Immunologic Laboratory Techniques Practice Questions

Question 1

All of the following forces are involved in antigen-antibody reactions, except:

Accepted Answer

Covalent bond

Answer

Electrostatic bond

Answer

Hydrogen bond

Answer

Van der Waals forces

Question 2

Which of the following is used to detect abnormal gene sequences EXCEPT?

Accepted Answer

Flow cytometry

Answer

RFLP analysis

Answer

Pyrosequencing

Answer

FISH

Question 3

Among the biochemical methods of genetic engineering, the Western Blot detects:

Accepted Answer

Protein

Answer

DNA

Answer

mRNA

Answer

RNA

Question 4

Best method to diagnose HIV in an infant?

Accepted Answer

PCR

Answer

ELISA

Answer

Western blot

Answer

All of the options

Question 5

What is the Rose Waaler test used for?

Accepted Answer

Passive hemagglutination test

Answer

Ring precipitation

Answer

Precipitation in gel

Answer

Complement fixation test

Question 6

The graphical representation for flow cytometry analysis is done by which of the following?

Accepted Answer

Histogram, dot plot

Answer

Pie chart, dot plot

Answer

Line diagram, dot plot

Answer

Bar diagram, dot plot

Question 7

A 30-year-old male presents with rapidly progressive renal failure over 3 weeks, haematuria, and red cell casts in urine. Serum creatinine has risen from 1.2 to 7.8 mg/dL within one month. ANCA is positive. The renal biopsy is shown in Image 3. Which of the following statements best describes the cellular composition and origin of the lesion most prominently seen in this biopsy?

Accepted Answer

A. Proliferating parietal epithelial cells of Bowman's capsule and infiltrating macrophages forming a compressive extra-capillary lesion

Answer

B. Proliferating visceral epithelial cells (podocytes) with mesangial expansion forming a segmental sclerosing lesion

Answer

C. Proliferating endothelial cells and mesangial cells with subendothelial immune deposits forming a diffuse proliferative lesion

Answer

D. Proliferating tubular epithelial cells with interstitial fibroblasts forming a periglomerular fibrotic lesion

Question 8

Secondary amyloidosis complicates which of the following conditions?

Accepted Answer

Chronic osteomyelitis

Answer

Pneumonia

Answer

Chronic glomerulonephritis

Answer

Irritable bowel syndrome

Question 9

Hyperacute rejection is due to which of the following mechanisms?

Accepted Answer

Preformed antibodies

Answer

Cytotoxic T lymphocyte mediated injury

Answer

Endothelitis caused by donor antibodies

Answer

Circulating macrophage mediated injury

Question 10

Which of the following cells do not act as antigen-presenting cells?

Accepted Answer

T-cells

Answer

B-cells

Answer

Macrophages

Answer

Osteoclasts

Immunologic Laboratory Techniques — MCQs

Immunologic Laboratory Techniques — MCQs

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