Bleeding Disorders Practice Questions

Question 1

Disseminated intravascular coagulation (DIC) differs from thrombotic thrombocytopenic purpura. In this reference, DIC is most likely characterized by:

Accepted Answer

Low levels of coagulation factors

Answer

Elevated reticulocyte count

Answer

Severe thrombocytopenia

Answer

Presence of schistocytes in the blood smear

Question 2

A 9-year-old girl has a bleeding diathesis, with prolonged activated partial thromboplastin time (APTT) but normal prothrombin time (PT) and normal platelet count. The diagnosis is?

Accepted Answer

Von Willebrand's disease

Answer

Factor V deficiency

Answer

Haemophilia A

Answer

Haemophilia B

Question 3

Which of the following statements regarding von Willebrand disease is incorrect?

Accepted Answer

Type 1 von Willebrand disease presents with severe bleeding since childhood.

Answer

Type 2 von Willebrand disease is associated with a moderate bleeding tendency.

Answer

Type 3 von Willebrand disease is associated with severe deficiency of factor VIII.

Answer

Type 2 von Willebrand disease includes subtypes with varying defects in von Willebrand factor.

Question 4

Factor V mutation most commonly initially presents as:-

Accepted Answer

Deep Vein Thrombosis (DVT)

Answer

Thrombosis

Answer

Disseminated Intravascular Coagulation (DIC)

Answer

Pulmonary Embolism

Question 5

Following injury to a blood vessel, immediate hemostasis is achieved by:

Accepted Answer

Vasoconstriction

Answer

Fibrin deposition

Answer

Platelet adhesion

Answer

Thrombosis

Question 6

Glanzmann thrombasthenia is due to defect in:-

Accepted Answer

Gp IIb/IIIa

Answer

Gp VI

Answer

Thromboxane A2

Answer

Gp Ia/IIa

Question 7

A bone marrow aspirate shows blast cells with multiple Auer rods arranged in bundles ('faggot cells'). Which molecular finding would confirm acute promyelocytic leukemia?

Accepted Answer

PML-RARA translocation

Answer

BCR-ABL translocation

Answer

AML1-ETO translocation

Answer

inv(16) mutation

Question 8

All of the following are seen in polycythemia rubra vera except :

Accepted Answer

Decreased LAP Score

Answer

Increased platelets

Answer

Increased Vit B12 binding capacity (>9000 micromols/dL)

Answer

Leucocytosis

Question 9

Adenoidectomy is contraindicated in:

Accepted Answer

Bleeding disorder

Answer

SOM

Answer

CSOM

Answer

None of the options

Question 10

Which of the following is the most common myeloproliferative disorder?

Accepted Answer

Essential Thrombocythemia

Answer

Polycythemia rubra vera

Answer

CML

Answer

Myelofibrosis

Bleeding Disorders — MCQs

Bleeding Disorders — MCQs

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