Acute Leukemias — MCQs

A 55-year-old male with fatigue and a palpable spleen is found to have a high white cell count predominantly consisting of mature lymphocytes. What is the most likely diagnosis?

What is the cell of origin of B-cell Acute Lymphoblastic Leukemia (B-ALL)?

In the context of myelodysplastic syndromes (MDS) and acute myelogenous leukemia (AML), which of the following cytogenetic abnormalities is associated with the worst prognosis?

Specific stain for myeloblasts is

Which of the following is used to detect abnormal gene sequences EXCEPT?

Among the following AML subtypes, non-specific esterase (NSE) staining is typically NEGATIVE in which one?

A 34-year-old female presented with low hemoglobin, platelet count of $25,000 / \mathrm{mm}^{3}$, raised PT and APTT. The image shows a peripheral smear. Which of the following fusion genes is affected?

What is the most common type of acute myeloid leukemia in patients with Down's syndrome?

BCR-ABL fusion gene is MOST CHARACTERISTICALLY seen in?

A bone marrow aspirate shows blast cells with multiple Auer rods arranged in bundles ('faggot cells'). Which molecular finding would confirm acute promyelocytic leukemia?