Accumulations and Deposits Practice Questions

Question 1

Which type of necrosis is characterized by deposition of immune complexes and fibrin in the walls of blood vessels?

Accepted Answer

Fibrinoid necrosis

Answer

Liquefactive necrosis

Answer

Coagulative necrosis

Answer

Caseous necrosis

Question 2

False regarding Alzheimer's disease (AD) is:

Accepted Answer

Extracellular inclusion (lesion) can occur in the absence of intracellular inclusions to make pathological diagnosis of AD

Answer

Number of neurofibrillary tangles is associated with the severity of dementia

Answer

Number of senile (neuritic) plaques correlates (increases) with age

Answer

Presence of tau protein suggest neurodegeneration

Question 3

A skin biopsy shows 'snowstorm' appearance on polarized microscopy. Which histological finding would best confirm gouty tophi?

Accepted Answer

Needle-shaped crystals

Answer

Rhomboid crystals

Answer

Malta crosses

Answer

Apple-green birefringence

Question 4

Microvesicular fatty liver is caused by ?

Accepted Answer

Valproate

Answer

Chronic diabetes mellitus (DM)

Answer

Prolonged starvation

Answer

Chronic inflammatory bowel disease (IBD)

Question 5

Mr. Lallu, aged 54 years, who is a known diabetic patient, develops cirrhosis. There is associated skin hyperpigmentation and restrictive cardiomyopathy. Which of the following is the best initial test to diagnose this case?

Accepted Answer

Serum ferritin

Answer

Serum ceruloplasmin

Answer

Serum copper

Answer

Iron binding capacity

Question 6

Which of the following statements regarding cell aging is true?

Accepted Answer

Lipofuscin accumulates in cells with aging.

Answer

Free radicals cause cellular damage.

Answer

Mitochondrial content decreases with age.

Answer

Cell size typically decreases with aging.

Question 7

Which type of amyloidosis is seen in the patients going through dialysis?

Accepted Answer

A-beta 2

Answer

A-beta

Answer

AL

Answer

aTTR

Question 8

Size of fibrillary proteins in amyloidosis is:

Accepted Answer

7.5-10 nm

Answer

0-5 nm

Answer

12-17 nm

Answer

18-20 nm

Question 9

Identify the correct statement regarding Amyloidosis?

Accepted Answer

Amyloid deposits have beta pleated sheet conformation

Answer

Secondary amyloidosis is AL

Answer

Amyloidosis is called so because of deposition of complex carbohydrates

Answer

All of the options

Question 10

In amyloidosis, beta pleated sheets can be directly visualized at the molecular level using:

Accepted Answer

X-ray crystallography

Answer

Electron microscope

Answer

Congo red stain

Answer

Cryo-electron microscopy

Accumulations and Deposits — MCQs

Accumulations and Deposits — MCQs

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