Question 1

Q: A 40-year-old patient presented with heartburn and increased salivation. Upper GI endoscopy was done, and a biopsy was taken. What is the diagnosis based on the biopsy findings (image shown below)?

Barrett's esophagus. ***Barrett's esophagus*** - Characterized by **intestinal metaplasia** of the esophageal lining [1], often due to chronic gastroesophageal reflux disease (GERD) [1]. - Frequently presents with **heartburn** and increased salivation due to reflux [1], making it a likely diagnosis here. *Squamous cell carcinoma* - Typically associated with **dysphagia** and weight loss, not primarily with heartburn and increased salivation. - More common in the **upper and middle third of the esophagus** [2], unlike Barrett's which occurs in the lower esophagus. *Esophagitis* - Often presents with **painful swallowing** and inflammation, but not specifically distinguished by the metaplasia observed in Barrett's esophagus. - May cause heartburn, but increased salivation is less common and does not imply a pre-cancerous condition. *Adenocarcinoma* - While this is often associated with Barrett's esophagus, it presents with more severe symptoms like **weight loss** and significant dysphagia [3]. - Requires a biopsy for definitive diagnosis, and symptoms alone do not conclusively indicate adenocarcinoma without malignancy indicators. **References:** [1] Cross SS. Underwood's Pathology: A Clinical Approach. 6th ed. Common Clinical Problems From Alimentary System Disease, pp. 348-349. [2] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. The Gastrointestinal Tract, pp. 766-767. [3] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. The Gastrointestinal Tract, pp. 765-766.

Question

A 40-year-old patient presented with heartburn and increased salivation. Upper GI endoscopy was done, and a biopsy was taken. What is the diagnosis based on the biopsy findings (image shown below)?

Accepted Answer

Barrett's esophagus

Answer

Adenocarcinoma of the esophagus

Answer

Esophagitis due to reflux

Answer

Squamous cell carcinoma of the esophagus

Gastrointestinal Pathology — MCQs

Gastrointestinal Pathology — MCQs

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