Corneal Topography and Tomography — MCQs
Which of the following is not a feature of keratoconus?
Keratometry is done to assess:
Using the formula for Ponderal Index (PI = weight in kg / (height in m)^3), calculate the Ponderal index of a baby weighing 2000 grams and measuring 50 centimeters in length at birth.
Identify the diagnosis based on the clinical image shown.
Which keratometry reading is most accurate in post-LASIK eyes for IOL power calculation?
In a patient with a metallic foreign body in the eye, which investigation should NOT be done?
Statement 1 - A 59-year-old patient presents with flaccid bullae. Histopathology shows a suprabasal acantholytic split. Statement 2 - The row of tombstones appearance is diagnostic of Pemphigus vulgaris.
A lady wants LASIK surgery for her daughter. All the following are indications for performing LASIK surgery, except:
A lady wants LASIK surgery for her daughter. She asks for your opinion. All the following things are suitable for performing LASIK surgery except:
Which of the following is used for the treatment of Myopia?
Corneal Topography and Tomography Indian Medical PG Practice Questions and MCQs
Question 1: Which of the following is not a feature of keratoconus?
- A. Haab's striae (Correct Answer)
- B. Irregular astigmatism
- C. Scissoring reflex
- D. Munson's sign
Explanation: ***Haab's striae*** - **Haab's striae** are characteristic of congenital glaucoma, presenting as horizontal breaks in Descemet's membrane due to increased intraocular pressure and corneal stretching. - In contrast, keratoconus involves **vertical breaks in Descemet's membrane** (due to corneal thinning and protrusion), known as Vautin's striae or Vogt's striae, not Haab's striae. *Irregular astigmatism* - **Irregular astigmatism** is a hallmark of keratoconus, resulting from the asymmetric and non-uniform thinning and protrusion of the cornea. - This irregular corneal shape leads to a significant reduction in visual acuity that cannot be fully corrected with spherical or regular cylindrical lenses. *Scissoring reflex* - The **scissoring reflex** (or scissoring phenomena) is an objective finding observed during retinoscopy in patients with keratoconus, indicating significant irregular astigmatism. - It refers to the opposing movements of the retinoscopic reflex, resembling the opening and closing of scissors, as the light across the pupil is neutralized. *Munson's sign* - **Munson's sign** is a classic clinical finding in advanced keratoconus, where the lower eyelid protrudes in a V-shape when the patient looks downwards. - This protrusion is caused by the conical shape of the cornea pushing against the eyelid.
Question 2: Keratometry is done to assess:
- A. Corneal thickness
- B. Curvature of cornea (Correct Answer)
- C. Corneal sensation
- D. Corneal endothelium
Explanation: ***Curvature of cornea*** - **Keratometry** is specifically designed to measure the **radius of curvature of the anterior surface of the cornea**. - This measurement is essential for detecting and quantifying **astigmatism** and for fitting **contact lenses** and calculating **intraocular lens (IOL) power**. *Corneal thickness* - **Corneal thickness** is measured by **pachymetry**, not keratometry. - Pachymetry is used to assess conditions like **corneal edema** or prior to certain refractive surgeries. *Corneal sensation* - **Corneal sensation** is tested using a fine wisp of cotton or a **corneal aesthesiometer**. - This evaluates the integrity of the **corneal nerves** and blink reflex. *Corneal endothelium* - The **corneal endothelium** is assessed using **specular microscopy** to evaluate cell count, size, and shape. - This is important for surgical planning and monitoring **corneal dystrophies**.
Question 3: Using the formula for Ponderal Index (PI = weight in kg / (height in m)^3), calculate the Ponderal index of a baby weighing 2000 grams and measuring 50 centimeters in length at birth.
- A. 32
- B. 8
- C. 4
- D. 16 (Correct Answer)
Explanation: ***16*** - Begin by converting the baby's weight from grams to kilograms: 2000 grams = **2 kg**. - Next, convert the baby's height from centimeters to meters: 50 centimeters = **0.5 m**. - Apply the Ponderal Index formula: PI = weight (kg) / (height (m))³ = 2 kg / (0.5 m)³ - Calculate (0.5)³ = 0.5 × 0.5 × 0.5 = **0.125** - Therefore: PI = 2 / 0.125 = **16** - This value indicates a relatively thin baby, consistent with the **low birth weight of 2000 grams**. *8* - This incorrect value would result from errors in the calculation, such as incorrectly computing (0.5)³ or making arithmetic mistakes in the division. - The correct calculation yields 16, not 8. *32* - This result would occur if the weight was incorrectly doubled (4 kg instead of 2 kg) in the calculation. - Alternatively, this could result from incorrectly calculating the denominator as (0.5)³ = 0.0625 instead of 0.125. *4* - This answer might arise from dividing by (0.5)² = 0.25 instead of (0.5)³ = 0.125, essentially using a squared power instead of cubed. - Or from incorrectly converting the weight to 0.5 kg instead of 2 kg.
Question 4: Identify the diagnosis based on the clinical image shown.
- A. Horner-Trantas spots
- B. Herbert's pits (Correct Answer)
- C. Pannus
- D. Corneal dystrophy
Explanation: ***Herbert's pits*** - The image displays characteristic **pits at the limbus**, which are a hallmark of healed follicular conjunctivitis, specifically **Herbert's pits**. - These pits are pathognomonic for **trachoma**, a chronic keratoconjunctivitis caused by *Chlamydia trachomatis*. *Horner-Trantas spots* - These are small, raised, gelatinous white dots found at the limbus, typically containing **eosinophils**. - They are characteristic of **vernal keratoconjunctivitis**, an allergic inflammatory condition, and not seen in the provided image. *Pannus* - **Pannus** refers to the growth of **vascularized connective tissue** onto the cornea. - While pannus is also a feature of trachoma, the image specifically shows distinct limbal pits, rather than diffuse vascularization. *Corneal dystrophy* - **Corneal dystrophies** are a group of inherited, bilateral, and progressive corneal disorders that manifest as opacities or structural changes in the cornea. - The findings in the image, such as pits, are inflammatory in origin and distinct from the typically stromal or epithelial changes seen in corneal dystrophies.
Question 5: Which keratometry reading is most accurate in post-LASIK eyes for IOL power calculation?
- A. Topography-derived K
- B. Total corneal power (Correct Answer)
- C. Manual keratometry
- D. Automated keratometry
Explanation: ***Total corneal power*** * After LASIK, the **anterior and posterior corneal curvatures** are altered, leading to discrepancies in standard keratometry readings. * **Total corneal power** methods, such as those derived from **corneal tomography** or **anterior segment OCT**, account for both surfaces, providing a more accurate estimation of the true refractive power. * *Topography-derived K* * While corneal topography is valuable for assessing the anterior corneal surface and identifying **irregular astigmatism**, it traditionally focuses on the anterior curvature and may not fully account for the altered **posterior corneal surface** after LASIK. * Standard topography-derived K values often rely on assumptions about the posterior-to-anterior corneal curvature ratio, which are invalid after refractive surgery. * *Manual keratometry* * Manual keratometry measures the **anterior corneal curvature** at a few discrete points and is highly susceptible to inaccuracies due to the post-LASIK changes in corneal shape. * It tends to **overestimate the corneal power** in eyes that have undergone myopic LASIK and **underestimate it** in hyperopic LASIK, leading to significant IOL power calculation errors. * *Automated keratometry* * Similar to manual keratometry, automated keratometry primarily measures the **anterior corneal surface** and relies on a fixed refractive index ratio that is no longer valid after corneal reshaping. * These devices generally provide **inaccurate keratometry readings** in post-refractive surgery eyes, contributing to refractive surprises after cataract surgery.
Question 6: In a patient with a metallic foreign body in the eye, which investigation should NOT be done?
- A. X-ray
- B. MRI (Correct Answer)
- C. CT
- D. USG
Explanation: ***MRI*** - **Magnetic Resonance Imaging (MRI)** is contraindicated in patients with suspected **metallic foreign bodies** in the eye. - The powerful magnetic fields of an MRI can cause the metallic object to move, potentially leading to further **tissue damage** or even loss of vision. *X-ray* - **X-rays** are often the initial investigation of choice for detecting **radio-opaque foreign bodies** within the eye. - They can effectively localize larger metallic objects and are readily available in most emergency settings. *CT* - **Computed Tomography (CT)** scans provide detailed cross-sectional images and are excellent for precisely localizing **intraocular foreign bodies**, especially smaller ones. - CT can differentiate between metallic and non-metallic objects and assess for associated injuries like orbital fractures. *USG* - **Ultrasound (USG)** of the eye can be useful for detecting **intraocular foreign bodies**, especially if they are non-metallic or located in the posterior segment. - It can also assess for associated complications such as **retinal detachment** or vitreous hemorrhage.
Question 7: Statement 1 - A 59-year-old patient presents with flaccid bullae. Histopathology shows a suprabasal acantholytic split. Statement 2 - The row of tombstones appearance is diagnostic of Pemphigus vulgaris.
- A. Statements 1 & 2 are correct, 2 is not explaining 1 (Correct Answer)
- B. Statements 1 and 2 are correct and 2 is the correct explanation for 1
- C. Statements 1 and 2 are incorrect
- D. Statement 1 is incorrect
Explanation: ***Correct: Statements 1 & 2 are correct, 2 is not explaining 1*** **Analysis of Statement 1:** - A 59-year-old patient with **flaccid bullae** and **suprabasal acantholytic split** on histopathology is the classic presentation of **Pemphigus vulgaris** - The flaccid (easily ruptured) nature of bullae distinguishes it from tense bullae seen in bullous pemphigoid - The suprabasal location of the split (just above the basal layer) with acantholysis (loss of cell-to-cell adhesion) is pathognomonic - **Statement 1 is CORRECT** ✓ **Analysis of Statement 2:** - The **"row of tombstones" or "tombstone appearance"** is indeed a diagnostic histopathological feature of Pemphigus vulgaris - This appearance results from basal keratinocytes remaining attached to the basement membrane while suprabasal cells separate due to acantholysis - The intact basal cells standing upright resemble a row of tombstones - **Statement 2 is CORRECT** ✓ **Does Statement 2 explain Statement 1?** - Statement 2 describes a **histopathological appearance** (tombstone pattern) that is a **consequence** of the suprabasal split - However, it does NOT explain the **underlying cause** of the flaccid bullae or the suprabasal split - The true explanation involves **IgG autoantibodies against desmoglein 3 (and desmoglein 1)**, which attack intercellular adhesion structures (desmosomes), causing **acantholysis** - Therefore, **Statement 2 does NOT explain Statement 1** ✗ *Incorrect: Statement 2 is the correct explanation for Statement 1* - While both statements describe features of Pemphigus vulgaris, the tombstone appearance is a descriptive finding, not an explanatory mechanism *Incorrect: Statements 1 and 2 are incorrect* - Both statements are medically accurate descriptions of Pemphigus vulgaris features *Incorrect: Statement 1 is incorrect* - Statement 1 correctly describes the cardinal clinical and histopathological features of Pemphigus vulgaris
Question 8: A lady wants LASIK surgery for her daughter. All the following are indications for performing LASIK surgery, except:
- A. Stable refraction for 1 year
- B. Corneal thickness of 600 microns
- C. Age of 15 years (Correct Answer)
- D. Myopia of 4 Diopters
Explanation: ***Age of 15 years*** - LASIK surgery is generally not recommended for individuals under the age of 18, as their eyes and **refractive error** are still developing and stabilizing. - Performing LASIK on a 15-year-old could lead to **regression** of the refractive correction as the eye continues to grow. *Myopia of 4 Diopters* - A **myopia** of 4 Diopters (D) falls within the treatable range for LASIK, which can effectively correct moderate degrees of nearsightedness. - This is a common indication for individuals seeking freedom from glasses or contact lenses. *Stable refraction for 1 year* - **Stable refraction** for at least one year is a crucial criterion for LASIK, ensuring that the patient's prescription is unlikely to change significantly post-surgery. - Unstable refraction could result in suboptimal visual outcomes and the need for further correction. *Corneal thickness of 600 microns* - A **corneal thickness** of 600 microns is considered well within the safe range for LASIK surgery, allowing sufficient residual stromal bed after flap creation and ablation. - Adequate corneal thickness is essential to prevent complications such as **corneal ectasia**.
Question 9: A lady wants LASIK surgery for her daughter. She asks for your opinion. All the following things are suitable for performing LASIK surgery except:
- A. Myopia of 4 Diopters
- B. Age of 15 years (Correct Answer)
- C. Stable refraction for 1 year
- D. Corneal thickness of 600 microns
Explanation: ***Age of 15 years*** - LASIK surgery is generally not recommended for individuals under the age of 18 because their **refractive error** may still be changing. - Ensuring **refractive stability** is crucial for long-term success of the procedure. *Myopia of 4 Diopters* - This level of **myopia** (nearsightedness) is well within the treatable range for LASIK surgery. - LASIK can effectively correct moderate myopia for improved vision. *Stable refraction for 1 year* - **Refractive stability** for at least one year is a critical prerequisite for LASIK, indicating that the patient's prescription is no longer changing significantly. - This stability ensures that the surgical correction will be lasting and accurate. *Corneal thickness of 600 microns* - A corneal thickness of 600 microns is considered **more than adequate** for LASIK surgery, as it allows for the creation of a corneal flap and subsequent ablation without compromising corneal integrity. - The minimum required corneal thickness typically falls around 500 microns, with values above this being favorable.
Question 10: Which of the following is used for the treatment of Myopia?
- A. Nd–YAG LASER
- B. Excimer Laser (Correct Answer)
- C. Carbamazepine
- D. SSRI
Explanation: **Explanation:** **Correct Answer: B. Excimer Laser** The **Excimer laser** (Argon-Fluoride gas, 193 nm wavelength) is the gold standard for corneal refractive surgeries like **LASIK, PRK, and SMILE**. It works via **photoablation**, a process where high-energy ultraviolet light breaks molecular bonds in the corneal stroma without generating heat (cold laser). In myopia, the Excimer laser is used to flatten the central cornea, thereby reducing its refractive power so that light focuses accurately on the retina. **Incorrect Options:** * **A. Nd:YAG Laser (1064 nm):** This is a solid-state laser used for **photodisruption**. Its primary uses in ophthalmology include Posterior Capsulotomy (for PCO) and Peripheral Iridotomy (for Angle-Closure Glaucoma). It is not used for reshaping the cornea. * **C. Carbamazepine:** This is an anticonvulsant and the first-line treatment for **Trigeminal Neuralgia**. It has no role in treating refractive errors. * **D. SSRIs (Selective Serotonin Reuptake Inhibitors):** These are antidepressants. In ophthalmology, they are clinically significant because they can occasionally cause mydriasis and precipitate acute angle-closure glaucoma, but they do not treat myopia. **High-Yield Clinical Pearls for NEET-PG:** 1. **Laser Wavelengths:** Excimer (193 nm), Nd:YAG (1064 nm), Argon (514 nm - used for photocoagulation in diabetic retinopathy). 2. **Femtosecond Laser:** Used in "Bladeless LASIK" to create the corneal flap; it operates at 1053 nm. 3. **Contraindications for LASIK:** Thin cornea (<450-480 μm), Keratoconus, and unstable refractive error. 4. **SMILE (Small Incision Lenticule Extraction):** The newest refractive procedure that uses only a Femtosecond laser, eliminating the need for a corneal flap.
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