Beta-lactamase Producing Organisms Practice Questions

Question 1

All are true about ESBL except -

Accepted Answer

Resistant to carbapenems

Answer

Classification is based on 3rd generation cephalosporin sensitivity

Answer

Cephalosporin sensitivity testing is required to confirm ESBL

Answer

Ambler classification is based on molecular structure

Question 2

Which of the following is NOT a mechanism of antibiotic resistance?

Accepted Answer

Increased drug absorption

Answer

Efflux pump activity

Answer

Inactivation by enzymes such as beta-lactamase

Answer

Modification of drug target sites

Question 3

Carbapenem which has a tendency to cause maximum seizures?

Accepted Answer

Imipenem

Answer

Ertapenem

Answer

Doripenem

Answer

Meropenem

Question 4

Which class of antibiotics is primarily inactivated by extended-spectrum β-lactamases (ESBLs)?

Accepted Answer

Third-generation cephalosporins

Answer

Macrolides

Answer

Quinolones

Answer

Aminoglycosides

Question 5

All the following statements are true regarding beta-lactams except:

Accepted Answer

Aztreonam shows cross-reactivity with cephalexin.

Answer

Methicillin is not orally bioavailable and is given parenterally.

Answer

Imipenem should be given with cilastatin

Answer

Meropenem does not require cilastatin for protection against renal toxicity.

Question 6

Production of inactivating enzymes is an important mechanism of drug resistance for all of these antibiotics EXCEPT

Accepted Answer

Quinolone

Answer

Penicillin

Answer

Chloramphenicol

Answer

Aminoglycoside

Question 7

Which of the following bacteria is classified as facultative anaerobe?

Accepted Answer

Escherichia

Answer

Bacteroides

Answer

Pseudomonas

Answer

Clostridium

Question 8

A person returns to Delhi from Bangladesh after 2 days and has diarrhea. Stool examination shows RBC's in stool. The likely organism causing is ?

Accepted Answer

Shigella dysenteriae

Answer

Enteropathogenic E. Coli

Answer

Salmonella typhi

Answer

Enterotoxigenic E. Coli

Question 9

The bacterial drug resistance in tuberculosis results from which mechanism?

Accepted Answer

Mutation

Answer

Transduction

Answer

Transformation

Answer

Plasmid mediated resistance

Question 10

How does Staphylococcus aureus become resistant to methicillin?

Accepted Answer

Transpeptidase

Answer

Heat shock protein

Answer

Protein A

Answer

Protein C

Beta-lactamase Producing Organisms — MCQs

Beta-lactamase Producing Organisms — MCQs

Want unlimited practice?