Rheumatology and Immunology — MCQs

In which of the following conditions is the proximal interphalangeal joint involved while the distal interphalangeal joint is spared?

A 25-year-old female presents with a history of fever and oral ulcers and has developed erythematous lesions on her face. What is the most likely diagnosis?

A 45-year-old woman presents with a 4-month history of severe headaches and pain and blanching of the hands upon exposure to cold. She is a nonsmoker. Over the past 6 months, she has noticed progressive difficulty in swallowing solid food. Physical examination reveals smooth and tight skin over the face and fingers. The serologic test for anti-Scl-70 (anti topoisomerase) is positive. Painful hands in this patient are best described using which of the following terms?

Elevated ESR is seen in the following conditions except?

Which joint is NOT typically involved in Rheumatoid Arthritis?

In which of the following conditions is rheumatoid factor not present in serum?

A 35-year-old woman consults a physician because of increasing discomfort in her hands over the past year. Her symptoms have developed insidiously and are often worst for the first hour after rising. She has also been experiencing vague symptoms of fatigue and malaise, particularly in the early afternoon. Physical examination of her hands is notable for tenderness and synovial thickening of most of the small hand joints of both hands, particularly the proximal interphalangeal and metacarpophalangeal joints. A number of joints elsewhere, including in the feet, elbows, and ankles, are also symmetrically involved. An autoantibody directed against IgG is detected in serum. Which of the following is the most likely diagnosis?

A 30-year-old male presents with sudden onset pain, swelling, and redness of the left first metatarsophalangeal joint. A needle aspirate of the joint shows needle-shaped, negatively birefringent crystals. The physician prescribed a drug for the patient, but he developed nausea, vomiting, and diarrhea on the next day after taking the medication. Which of the following is the most likely drug that was prescribed to this patient?

Osteoarthritis involves which of the following joints except?

Which condition is characterized by a positive c-ANCA?