Polypharmacy and Deprescribing — MCQs

Which of the following drugs is not useful in the rehabilitation of alcoholic patients?

The therapeutic index of a drug is defined as the ratio between the toxic dose and the effective dose.

Which of the following is the most appropriate treatment for an overactive bladder in a patient with dementia?

Which of the following drugs should be given in a sustained-release oral dosage form?

Which of the following best describes a Type B adverse drug reaction?

A 56-year-old man is brought to the emergency department by his wife because of memory loss and difficulty walking. She has noticed personality changes, truancy from work, and lack of personal care over the past 1 year. On examination, he appears unkempt, smells of urine, and is uncooperative. He cannot recall the date or season and gets angry when asked questions. His answers are often fabricated when checked with his wife. The blood pressure is 150/90 mm Hg, pulse 100/min, and he is diaphoretic and tremulous. His gait is wide-based, and motor strength and reflexes are normal. His ocular movements are normal, but there is nystagmus on lateral gaze. In the past, he has had multiple admissions for alcohol withdrawal. Which of the following is the most appropriate next step in management?

The drug that causes fall in elderly patients with postural hypotension is:-

A 45-year-old man presents with a history of frequent falls. He has difficulty in looking down also. What is the most probable diagnosis -

Reversible dementia is a feature of which of the following conditions?

A 73-year-old woman presents to the clinic complaining of fatigue and feeling unwell. She notes the symptoms are worse on exertion but denies any chest pain or shortness of breath. Her past medical history is significant for hypertension and type 2 diabetes, both well-controlled on her current medications. On physical examination, vital signs are - blood pressure 135/80 mm Hg, pulse 72/min, and respiratory rate 10/min. The lungs are clear on auscultation, and heart sounds are normal. A CBC reveals a hemoglobin value of 9.5 g/dL and an MCV of 105 mm 3. Which of the following typically causes a macrocytic anemia?