Pharmacogenomics — MCQs

A patient on warfarin has a high INR. Which drug likely caused this?

Which of the following statements represents the most clinically significant aspect of drug metabolism?

Which drug is contraindicated in G6PD deficiency?

Which of the following cytochromes is involved in monooxygenase mediated detoxification of drugs?

A patient is on warfarin therapy. All of the following drugs increase the risk of bleeding with warfarin except?

Which of the following drugs is metabolized by CYP2D6?

Which of the following combinations can result in severe toxicity due to inhibition of cytochrome P450 enzymes?

A 22-year-old man presents with sudden loss of vision in his right eye. Physical examination reveals subluxation of the right crystalline lens. Auscultation of the chest reveals a midsystolic click. Echocardiography shows a floppy mitral valve and a dilated aortic arch. The patient's brother and cousin have similar symptoms. He has been prescribed a beta-blocker. A genetic defect involving which of the following substances is most likely present in this patient?

In X-linked recessive (XLR) diseases, a modified inheritance pattern called 'pseudodominance' occurs when?

Wilson's disease is inherited in which pattern?