Epigenetics and Disease Practice Questions

Question 1

Sumoylation of histone proteins is associated with

Accepted Answer

Transcription repression

Answer

Activation of gene transcription

Answer

Condensation of chromosome

Answer

DNA replication

Question 2

Deamination of methylated cytosine forms which of the following?

Accepted Answer

Thymine

Answer

Uracil

Answer

Cytosine

Answer

Guanine

Question 3

Which of the following best defines genomic imprinting?

Accepted Answer

Different expression of a gene depending on the parent of origin.

Answer

Expression of genes silenced on one chromosome through random X-inactivation.

Answer

Parent-specific gene expression due to chromosomal deletions only.

Answer

Uniparental disomy is a condition where both alleles come from one parent.

Question 4

DNA Methylation is not related to?

Accepted Answer

Capping

Answer

DNA Replication

Answer

Gene silencing

Answer

Mismatch repair

Question 5

Secondary leukemias are caused by

Accepted Answer

Alkylating agents

Answer

Antimetabolites

Answer

Vinca alkaloids

Answer

Actinomycin D

Question 6

Which of the following statements about gene therapy is false?

Accepted Answer

Gene therapy is only used for genetic disorders.

Answer

Gene also considered as drug

Answer

Gene therapy can be used to treat some cancers.

Answer

Has been tried in cystic fibrosis

Question 7

Identify the gene commonly involved in the condition shown in the image?

Accepted Answer

BRAF V600E

Answer

RAS

Answer

RET

Answer

P53

Question 8

Which of the following conditions is characterized by the presence of telangiectasia?

Accepted Answer

Hereditary hemorrhagic telangiectasia

Answer

Telangiectasia due to systemic sclerosis

Answer

Telangiectasia due to rosacea

Answer

Acquired telangiectasia due to sun exposure

Question 9

Gluten sensitive enteropathy is strongly associated with:-

Accepted Answer

HLA-DQ2

Answer

HLA-DQ3

Answer

Blood group B

Answer

HLA-DR4

Question 10

Which one of the following is an autosomal recessive disease?

Accepted Answer

Cystic fibrosis

Answer

Retinitis pigmentosa

Answer

Vitamin D resistant rickets

Answer

Neurofibromatosis

Epigenetics and Disease — MCQs

Epigenetics and Disease — MCQs

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