Pharmacogenomics and Precision Medicine — MCQs

The cytochrome involved in monooxygenase-mediated detoxification of drugs is:

What is the primary role of Cytochrome P450 enzymes in the liver?

What is the mechanism of metabolism for alcohol, aspirin, and phenytoin at high doses?

A patient with history of ischemic stroke was started on clopidogrel. However, she had another attack of stroke after 6 months. Which of the following is likely to be responsible for the failure of clopidogrel in this patient?

Which of the following cytochromes is involved in monooxygenase mediated detoxification of drugs?

A 50-year-old female with rheumatoid arthritis is being considered for infliximab therapy. Which of the following tests should be performed before beginning treatment?

A diabetic patient with Enterococcus faecalis sepsis, on intravenous Linezolid, developed high anion gap metabolic acidosis with increased serum lactate and negative ketones. What is the most probable acid-base abnormality?

A 46-year-old male presented to the emergency with muscle weakness and cramping. He has been taking hydrochlorothiazide for recently diagnosed hypertension. Which of the following is the most likely cause of his symptoms?

Immediately after eating, a man develops swelling of face and lips, respiratory distress, intense pruritus, hypotension, and a feeling of impending doom. What is the most likely diagnosis?

Antibiotic prophylaxis is indicated in which of the following procedures?