Mutations and DNA Repair Practice Questions

Question 1

Which of the following statements is true about silent mutations in a gene?

Accepted Answer

No change in Amino acid sequence in protein

Answer

No change in mRNA sequence

Answer

No change in protein expression

Answer

None of the above

Question 2

Which of the following is true about ataxia telangiectasia?

Accepted Answer

It is an autosomal recessive disease

Answer

There is absence of amphicytes in different organs

Answer

It is associated with normal immune function

Answer

Serum levels of IgA are increased

Answer

Serum alpha-fetoprotein levels are decreased

Question 3

Which of the following techniques can be used to detect single base pair substitutions?

Accepted Answer

PCR

Answer

FISH

Answer

Southern blot

Answer

Restriction Fragment Length Polymorphism (RFLP)

Question 4

Even conventional radiological procedures are contraindicated in which neurological disease?

Accepted Answer

Ataxia telangiectasia

Answer

Cockayne Syndrome

Answer

Gorlin Syndrome

Answer

All of the options

Question 5

Best method for the detection of mutations with low allele frequency is:

Accepted Answer

Droplet digital PCR

Answer

FISH

Answer

Sanger sequencing

Answer

Nested PCR

Question 6

Mutations are due to changes in:

Accepted Answer

DNA nucleotide sequence

Answer

RNA nucleotide sequence

Answer

Amino acid sequence of ribonuclease

Answer

Cell membrane

Question 7

Sun damage causes malignant transformation of the skin by:

Accepted Answer

Induction of pyrimidine dimers

Answer

Direct DNA damage

Answer

Free radical formation

Answer

Mutation of p53 due to UV exposure

Question 8

A patient presents with a skin rash that is exaggerated on sun exposure. What is the repair mechanism involved in this condition?

Accepted Answer

Nucleotide excision repair

Answer

Base excision repair

Answer

Mismatch repair

Answer

Double stranded DNA break repair

Question 9

DNA Methylation is not related to?

Accepted Answer

Capping

Answer

DNA Replication

Answer

Gene silencing

Answer

Mismatch repair

Question 10

Which of the following statements regarding mitochondrial DNA is FALSE?

Accepted Answer

All respiratory proteins are synthesized within the mitochondria

Answer

Double stranded

Answer

Inherited from mother

Answer

High mutation rate

Mutations and DNA Repair — MCQs

Mutations and DNA Repair — MCQs

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