Epigenetics and DNA Methylation Practice Questions

Question 1

Sumoylation of histone proteins is associated with

Accepted Answer

Transcription repression

Answer

Activation of gene transcription

Answer

Condensation of chromosome

Answer

DNA replication

Question 2

Phenotypic expression of a gene depending on the parent of origin is referred to as:

Accepted Answer

Genomic imprinting (parent-of-origin gene expression)

Answer

Mosaic genetic variation

Answer

Nonpenetrance of genotype

Answer

Genetic anticipation

Question 3

Deamination of methylated cytosine forms which of the following?

Accepted Answer

Thymine

Answer

Uracil

Answer

Cytosine

Answer

Guanine

Question 4

Which of the following statements about RNA capping is INCORRECT?

Accepted Answer

RNA capping occurs in the cytoplasm after transcription is complete.

Answer

RNA capping occurs in the nucleus and is co-transcriptional.

Answer

RNA capping involves the addition of a cap structure at the 5' end of the RNA molecule.

Answer

S-adenosyl methionine (SAM) acts as a methyl donor

Question 5

Which of the following statements about gene therapy is false?

Accepted Answer

Gene therapy is only used for genetic disorders.

Answer

Gene also considered as drug

Answer

Gene therapy can be used to treat some cancers.

Answer

Has been tried in cystic fibrosis

Question 6

Which one of the following statements about chromatin is not true?

Accepted Answer

H2A-H2B bind to both the entry and exit ends of DNA in nucleosomes

Answer

DNA winds approximately 1.75 times around the nucleosomes

Answer

Covalent modification of histones influence chromatin compaction

Answer

Non-histone proteins are part of mitotic chromosomes

Question 7

Assertion: DNA methylation leads to gene silencing. Reason: Methylation prevents binding of transcription factors to promoter regions.

Accepted Answer

Both assertion and reason are true and reason is the correct explanation.

Answer

Assertion is true but reason is false.

Answer

Both assertion and reason are true but reason is not the correct explanation.

Answer

Both assertion and reason are false.

Question 8

Effect of environment on genes is called?

Accepted Answer

Epigenetics

Answer

Euthenics

Answer

Positive Eugenics

Answer

Negative Eugenics

Question 9

DNA Methylation is not related to?

Accepted Answer

Capping

Answer

DNA Replication

Answer

Gene silencing

Answer

Mismatch repair

Question 10

Restriction fragment length polymorphism is used for:

Accepted Answer

Genetic mapping and identification

Answer

Detection of gene mutations

Answer

Paternity testing

Answer

Forensic analysis

Epigenetics and DNA Methylation — MCQs

Epigenetics and DNA Methylation — MCQs

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