DNA Replication and Repair Mechanisms Practice Questions

Question 1

Which of the following is true about ataxia telangiectasia?

Accepted Answer

It is an autosomal recessive disease

Answer

There is absence of amphicytes in different organs

Answer

It is associated with normal immune function

Answer

Serum levels of IgA are increased

Answer

Serum alpha-fetoprotein levels are decreased

Question 2

What is a key similarity between the processes of replication and transcription?

Accepted Answer

Involve phosphodiester bond formation with elongation occurring in the 5' - 3' direction.

Answer

Use RNA primers for initiation.

Answer

Use ribonucleotides as precursors.

Answer

Are semi-conservative events.

Question 3

The gaps between Okazaki fragments on the lagging strand during DNA replication are rejoined and sealed by:

Accepted Answer

DNA Ligase

Answer

DNA Helicase

Answer

DNA Phosphorylase

Answer

DNA Topoisomerase

Question 4

Mutations are due to changes in:

Accepted Answer

DNA nucleotide sequence

Answer

RNA nucleotide sequence

Answer

Amino acid sequence of ribonuclease

Answer

Cell membrane

Question 5

Which of the following is the etiology of Werner syndrome?

Accepted Answer

Short telomere with damaged DNA and loss of helicase

Answer

Increased length of telomere

Answer

Increased advanced glycation end products

Answer

Decreased lipid peroxidation

Question 6

Which one of the following statements about chromatin is not true?

Accepted Answer

H2A-H2B bind to both the entry and exit ends of DNA in nucleosomes

Answer

DNA winds approximately 1.75 times around the nucleosomes

Answer

Covalent modification of histones influence chromatin compaction

Answer

Non-histone proteins are part of mitotic chromosomes

Question 7

Which of the following doesn't occur in 5' to 3' direction?

Accepted Answer

RNA editing

Answer

DNA repair

Answer

Transcription

Answer

DNA replication

Question 8

Which of the following doesn't occur in 5' to 3' direction?

Accepted Answer

RNA editing

Answer

DNA replication

Answer

DNA repair

Answer

Transcription

Question 9

During DNA replication, if the template strand has the sequence 5'-GATTACA-3', what is the sequence of the complementary strand?

Accepted Answer

5'-TGTAATC-3'

Answer

5'-GATTACA-3'

Answer

3'-GATTACA-5'

Answer

5'-ACATTAG-3'

Question 10

What is the most important tool used in genetic engineering?

Accepted Answer

Restriction endonuclease

Answer

Topoisomerase

Answer

DNA Ligase

Answer

Helicase

DNA Replication and Repair Mechanisms — MCQs

DNA Replication and Repair Mechanisms — MCQs

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