Uncouplers and Inhibitors of Oxidative Phosphorylation Practice Questions

Question 1

In the electron transport chain (ETC), which enzyme does cyanide inhibit?

Accepted Answer

Cytochrome c oxidase (Complex IV)

Answer

Complex II (Succinate dehydrogenase)

Answer

Complex I (NADH dehydrogenase)

Answer

Complex III (Cytochrome bc1 complex)

Question 2

The inhibitor of the complex IV of the electron transport chain is

Accepted Answer

Hydrogen sulfide

Answer

Antimycin A

Answer

Barbiturates

Answer

Dimecaprol

Question 3

All are features of accidental hypothermia, EXCEPT

Accepted Answer

Increased number of FFA

Answer

Lactic acidosis

Answer

Bradycardia

Answer

Hypoglycemia

Question 4

Which of the following is a natural uncoupler found in brown adipose tissue?

Accepted Answer

Thermogenin

Answer

2,4-Nitrophenol

Answer

2,4-Dinitrophenol

Answer

Oligomycin

Question 5

Type IV complex of ETC is inhibited by

Accepted Answer

Cyanide

Answer

Antimycin

Answer

Oligomycin

Answer

CO2

Question 6

What is the mechanism of cyanide poisoning?

Accepted Answer

Inhibition of cytochrome oxidase

Answer

Inhibition of complex I

Answer

Inhibition of cytochrome C

Answer

Inhibition of carbonic anhydrase

Question 7

In ETC NADH generates -

Accepted Answer

3 ATPs

Answer

1 ATPs

Answer

4 ATPs

Answer

2 ATPs

Question 8

Inhibitor of F0F1 ATPase in the electron transport chain is

Accepted Answer

Oligomycin A

Answer

Antimycin A

Answer

2,4-Dinitrophenol

Answer

Barbiturates

Question 9

Final common pathway of metabolism of carbohydrates, lipids and proteins is?

Accepted Answer

TCA cycle

Answer

Gluconeogenesis

Answer

Glycogenesis

Answer

None of the options

Question 10

All are cofactors for Dehydrogenase except:

Accepted Answer

SAM

Answer

NADP

Answer

NAD

Answer

FAD

Uncouplers and Inhibitors of Oxidative Phosphorylation — MCQs

Uncouplers and Inhibitors of Oxidative Phosphorylation — MCQs

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