NEET-PG 2022 Practice Questions

Q: Which of the following statements is true regarding the telomerase theory of aging?

Decreased telomere length is associated with aging. ***Decreased telomere length is associated with aging*** - Telomeres are protective DNA-protein caps at chromosome ends that **shorten with each cell division** - Progressive telomere shortening triggers **cellular senescence** (Hayflick limit) and apoptosis - This mechanism directly contributes to aging and **age-related diseases** - The telomere theory of aging (Olovnikov hypothesis) states that telomere attrition is a primary driver of biological aging *Abnormal telomerase activation is associated with cancer* - **Telomerase is reactivated in ~85-90% of cancers**, enabling unlimited replicative potential - Normal adult somatic cells have low/absent telomerase activity - While telomerase can extend cellular lifespan, its aberrant activation leads to malignancy, not healthy aging *Telomere stability directly maintains chromosomal integrity* - Telomeres prevent chromosome degradation, end-to-end fusions, and DNA damage responses - This is a **protective function**, not the basis of the telomere theory of aging - The aging theory focuses on **consequences of telomere shortening**, not stability maintenance *Increased telomere length is associated with prolonged cellular lifespan* - Longer telomeres do correlate with younger biological age and extended replicative capacity - However, this describes the **inverse relationship** rather than the core aging theory - The telomere theory specifically explains aging through **progressive shortening**, not length extension

Q: The electron transport chain is a series of redox reactions that result in ATP synthesis. Which of the following is a cytochrome complex IV inhibitor?

Cyanide. ***Cyanide*** - **Cyanide** is a potent inhibitor of **cytochrome c oxidase (Complex IV)** in the electron transport chain, binding to the ferric iron (Fe3+) in the heme group of the enzyme. - This binding prevents the transfer of electrons to **oxygen**, thereby halting cellular respiration and ATP production. *Carbon dioxide* - **Carbon dioxide** is a metabolic waste product and a component of the **bicarbonate buffer system**, but it does not directly inhibit cytochrome complex IV. - While high levels can affect physiological pH and enzyme function, its primary role is not as an electron transport chain inhibitor. *Oligomycin* - **Oligomycin** inhibits **ATP synthase (Complex V)** by binding to its Fo subunit, which blocks the flow of protons through the ATP synthase channel. - This prevents the synthesis of ATP but does not directly affect the electron transfer steps of cytochrome complex IV. *Ouabain* - **Ouabain** is a cardiac glycoside that inhibits the **Na+/K+-ATPase pump** in the cell membrane. - It does not have any direct inhibitory effect on the components of the electron transport chain, including cytochrome complex IV.

Q: Which of the following agencies is primarily responsible for supporting school feeding programs globally?

WFP. ***WFP (World Food Programme)*** - **WFP** is the **primary UN agency** responsible for supporting **school feeding programs globally**, operating in over 60 countries and providing meals to millions of schoolchildren. - WFP's school feeding programs are the world's largest safety net initiative, combining hunger relief with education support, and are a **flagship program** of the organization. - The agency focuses specifically on food assistance and hunger, making school feeding programs a core component of their mission to achieve Zero Hunger. *UNICEF* - **UNICEF** does support child nutrition and welfare programs, including some school-based nutrition initiatives, but it is **not the primary agency** for school feeding programs. - UNICEF's broader mandate focuses on child rights, health, education, and protection, with nutrition being one component rather than the specialized focus that WFP has on food assistance. - UNICEF often **collaborates with WFP** on school feeding initiatives rather than leading them independently. *UNDP* - The **UNDP** (United Nations Development Programme) focuses on sustainable development, poverty alleviation, and resilient societies. - While food security is part of development goals, UNDP does not directly implement or primarily fund school feeding programs compared to WFP. *WHO* - The **WHO** (World Health Organization) is the leading international authority on public health, focusing on disease prevention, health standards, and health policy. - While WHO provides guidance on nutritional standards and healthy diets for children, it does **not implement or fund school feeding programs** - this operational role belongs to WFP.

Q: A patient presents with complaints of hair loss and behavioral changes noted by his wife. Upon examination, the doctor observes a loss of eyebrows. After further assessment, including an examination of the nails, what type of poisoning is suspected in this case?

Thallium. ***Thallium*** - **Thallium poisoning** characteristically presents with **hair loss (alopecia)**, including loss of eyebrows, and **neurological symptoms** such as behavioral changes. - It also causes nail changes like **Mees' lines** and is known for its **neurotoxic effects**. *Arsenic* - **Arsenic poisoning** primarily causes **gastrointestinal symptoms** (nausea, vomiting, diarrhea), **skin lesions** (hyperpigmentation, hyperkeratosis), and **neuropathy**. - While it can cause nail changes (Mees' lines), significant alopecia and loss of eyebrows are less prominent compared to thallium. *Mercury* - **Mercury poisoning** often leads to **neurological symptoms** (tremors, ataxia, irritability), kidney damage, and **gingivostomatitis**. - Hair loss and loss of eyebrows are not typical or prominent features of mercury toxicity. *Lead* - **Lead poisoning** is associated with **neurodevelopmental deficits** in children, **peripheral neuropathy**, **abdominal pain (lead colic)**, and **anemia**. - Alopecia and loss of eyebrows are not characteristic symptoms of lead toxicity.

Q: A female patient presents to you with a unilateral headache. It is associated with nausea, photophobia, and phonophobia. What is the drug of choice for acute management?

Sumatriptan. ***Sumatriptan*** - **Sumatriptan**, a **triptan**, is an effective abortive therapy for **acute migraine attacks** due to its selective serotonin 5-HT1B/1D receptor agonist action, leading to vasoconstriction and inhibition of neurogenic inflammation. - The symptoms described—**unilateral headache**, nausea, **photophobia**, and **phonophobia**—are classic features of migraine. *Flunarizine* - **Flunarizine** is a **calcium channel blocker** used for migraine **prophylaxis**, not for acute treatment. - It is typically prescribed for patients experiencing frequent or severe migraine attacks to reduce their incidence. *Propranolol* - **Propranolol** is a **beta-blocker** primarily used for migraine **prophylaxis**. - It helps prevent migraine attacks by modulating cerebral blood flow and neuronal excitability, but it is not effective for acute pain relief during an attack. *Topiramate* - **Topiramate** is an **antiepileptic drug** often used for migraine **prophylaxis**. - It works by various mechanisms, including altering neurotransmitter activity, but it does not provide acute symptomatic relief for an ongoing migraine attack.

Q: A delayed intravenous urogram of a patient is given below. What is the likely diagnosis?

Pelviureteric junction obstruction. ***Pelviureteric junction obstruction*** - The image shows marked **dilatation of the renal pelvis and calyces** on the right side, with a relatively abrupt narrowing at the junction of the pelvis and ureter. - The delayed nature of the urogram suggests **impaired drainage** of contrast from the renal pelvis, accumulating proximal to the obstruction. *Putty kidney* - A "putty kidney" (or **autonecrotic kidney**) refers to a chronic, severely diseased kidney, often seen in end-stage **renal tuberculosis**, that has become calcified and non-functional. - This image demonstrates active contrast excretion and pelvicalyceal dilatation, not a calcified, non-functional organ. *Staghorn calculus* - A staghorn calculus is a **large, branched kidney stone** that occupies a significant portion of the renal collecting system. - While it can cause hydronephrosis, the image does not show a dense, radiopaque calculus filling the collecting system. *Cystic kidney* - **Cystic kidneys**, such as in polycystic kidney disease, are characterized by multiple fluid-filled sacs within the kidney parenchyma. - The image depicts dilatation of the collecting system, not diffuse cystic changes throughout the renal parenchyma.

Q: The image below shows a pressure sore. Which stage does this belong to?

Stage 4. ***Stage 4*** - The image clearly shows **extensive tissue loss**, including exposed bone and muscle, indicating a **deep tissue injury**. - The presence of large areas of **dead tissue (eschar)**, undermining, and tunneling are characteristic features of a stage 4 pressure sore. *Stage 1* - This stage involves **intact skin** with non-blanchable redness, indicating only superficial damage. - There is no **break in the skin** or tissue loss in Stage 1 pressure sores. *Stage 2* - Characterized by **partial-thickness skin loss**, presenting as an open blister or shallow ulcer. - **No visible deeper tissue** such as fat, muscle, or bone is exposed in this stage. *Stage 3* - Involves **full-thickness skin loss** with visible subcutaneous fat, but bone, tendon, or muscle are not exposed. - While there may be **undermining or tunneling**, the deep structures are not yet visible as seen in the image.

Question 1

Which of the following statements is true regarding the telomerase theory of aging?

Accepted Answer

Decreased telomere length is associated with aging

Answer

Abnormal telomerase activation is associated with cancer

Answer

Telomere stability directly maintains chromosomal integrity

Answer

Increased telomere length is associated with prolonged cellular lifespan

Question 2

The electron transport chain is a series of redox reactions that result in ATP synthesis. Which of the following is a cytochrome complex IV inhibitor?

Accepted Answer

Cyanide

Answer

Carbon dioxide

Answer

Oligomycin

Answer

Ouabain

Question 3

Which of the following agencies is primarily responsible for supporting school feeding programs globally?

Accepted Answer

WFP

Answer

UNDP

Answer

UNICEF

Answer

WHO

Question 4

You are working in a primary health center (PHC) situated in a high seismic zone. Which of the following actions should you take as part of preparedness for an emergency?

Accepted Answer

Conduct a simulation for the disaster and assess the response.

Answer

Ensure all financial and other resources are available for disaster preparedness.

Answer

Increase public awareness through campaigns and loudspeakers.

Answer

Follow instructions given over the phone or radio by higher officials.

Question 5

A patient presents with complaints of hair loss and behavioral changes noted by his wife. Upon examination, the doctor observes a loss of eyebrows. After further assessment, including an examination of the nails, what type of poisoning is suspected in this case?

Accepted Answer

Thallium

Answer

Arsenic

Answer

Mercury

Answer

Lead

Question 6

An RTA patient presented to the emergency department with severe pain in the ankle. An X-ray was performed, given below. What is the best next step in management?

Accepted Answer

Neurovascular Assessment and Closed reduction with slab application

Answer

Neurovascular Assessment and Closed reduction with cast application

Answer

Neurovascular Assessment and Immediate surgery

Answer

Neurovascular Assessment and Immediate open reduction

Question 7

An 11-year-old child with a history of streptococcal pharyngitis presents you with fever and arthralgia. There is no past history of rheumatic heart disease or features of carditis or valvular disease. How often is 600,000 IU of benzathine penicillin recommended for prophylaxis of rheumatic heart disease?

Accepted Answer

Once in three weeks for 5 years or till the age of 18, whichever is longer

Answer

Immediately

Answer

Thrice weekly lifelong

Answer

Once in three weeks for 10 years or till the age of 25, whichever is longer

Question 8

A female patient presents to you with a unilateral headache. It is associated with nausea, photophobia, and phonophobia. What is the drug of choice for acute management?

Accepted Answer

Sumatriptan

Answer

Flunarizine

Answer

Propranolol

Answer

Topiramate

Question 9

A delayed intravenous urogram of a patient is given below. What is the likely diagnosis?

Accepted Answer

Pelviureteric junction obstruction

Answer

Putty kidney

Answer

Staghorn calculus

Answer

Cystic kidney

Question 10

The image below shows a pressure sore. Which stage does this belong to?

Accepted Answer

Stage 4

Answer

Stage 1

Answer

Stage 2

Answer

Stage 3

NEET-PG 2022

Biochemistry

Community Medicine

Forensic Medicine

Orthopaedics

Pediatrics

Pharmacology

Radiology

Surgery