NEET-PG 2015 Practice Questions

Q: Dermatitis may be a clinical manifestation of deficiency states of all of the following nutrients except -

Thiamine. ***Thiamine*** - A deficiency in **thiamine (vitamin B1)** primarily affects the nervous and cardiovascular systems, leading to conditions like **beriberi**, characterized by neuropathy, heart failure, and Wernicke-Korsakoff syndrome. - Dermatitis is **not a typical or direct clinical manifestation** of thiamine deficiency. *Biotin* - **Biotin (vitamin B7)** deficiency can cause **dermatitis**, often described as a scaly, erythematous rash around the eyes, nose, and mouth. - Hair loss (**alopecia**) and **neurological symptoms** are also associated with biotin deficiency. *Niacin* - **Niacin (vitamin B3)** deficiency leads to **pellagra**, classically presenting with the "3 Ds": **dermatitis**, **diarrhea**, and **dementia**. - The dermatitis in pellagra is typically symmetrical and photosensitive, affecting sun-exposed areas. *Pyridoxine* - **Pyridoxine (vitamin B6)** deficiency can result in **seborrheic dermatitis-like rash**, especially around the eyes, nose, and mouth. - Other symptoms include **glossitis**, **cheilosis**, and **neurological disturbances** like peripheral neuropathy.

Q: What do the Lines of Blaschko represent?

Patterns of cell migration. ***Patterns of cell migration*** - The **Lines of Blaschko** are invisible patterns in the skin reflecting the **movement and proliferation of cells** during embryonic development. - They become apparent in certain genetic conditions or mosaics when affected cells form streaks or swirls following these lines. *Patterns along lymphatics* - **Lymphatic patterns** refer to the distribution of the lymphatic system, which drains interstitial fluid and immune cells. - Skin conditions involving lymphatics often present as **lymphedema** or **lymphangitis**, which do not typically follow Blaschko's lines. *Patterns along blood vessels* - **Vascular patterns** describe the distribution of blood vessels in the skin, which can be affected in conditions like **livedo reticularis** or **vasculitis**. - These are distinct from Blaschko's lines, which are embryological in origin and not directly related to vascular anatomy. *Patterns along nerves* - **Nerve patterns** in the skin, such as **dermatomes**, correspond to the sensory innervation supplied by spinal nerves. - While some skin conditions can follow dermatomal distributions (e.g., **herpes zoster**), these are distinct from the embryological migration patterns represented by Blaschko's lines.

Q: Following delivery, a tear involving the perineum and external anal sphincter with intact mucosa is classified as which grade?

Third degree. ***Third degree*** - A third-degree perineal tear involves the **perineum** and the **external anal sphincter (EAS)**, either partially or completely, while the **anal mucosa remains intact**. - This classification is crucial for determining the necessary repair technique and predicting potential long-term complications related to **anal incontinence**. *First degree* - A first-degree tear involves only the **skin** of the perineum and the **vaginal mucosa**, without involving the underlying muscle. - These tears are typically superficial and may not even require suturing. *Second degree* - A second-degree tear involves the **perineal muscles** but does not extend to the anal sphincter. - It includes the vaginal mucosa, perineal skin, and muscles but spares the **external anal sphincter**. *Fourth degree* - A fourth-degree tear is the most severe, involving the **perineum**, **external anal sphincter**, and extending through the **anal mucosa**, exposing the rectal lumen. - These tears carry the highest risk of **fecal incontinence** and require meticulous surgical repair.

Q: A 28-year-old primigravida with 32 weeks of gestation presents with profuse vaginal discharge since yesterday. She was advised USG, which showed a single live intrauterine gestational sac with FL and AC corresponding to the weeks of gestation and AFI as adequate. What is the diagnosis?

Normal vaginal discharge. ***Normal vaginal discharge*** - Profuse vaginal discharge is a common and **physiological occurrence** in pregnancy due to increased estrogen levels and blood flow to the vagina. - The ultrasound findings of **adequate amniotic fluid index (AFI)** rule out rupture of membranes, and no other symptoms of infection are reported. *Preterm Premature Rupture of Membranes (PPROM)* - PPROM would present with a significant reduction in the **amniotic fluid index (AFI)** on ultrasound, which is noted as adequate in this case. - The discharge in PPROM is typically **amniotic fluid**, which is clear and watery, unlike mere profuse vaginal discharge. *Trichomoniasis* - This infection typically causes a **frothy, greenish-yellow discharge** with a foul odor, along with vulvar itching and irritation. - These characteristic symptoms are not mentioned in the patient's presentation. *Candidiasis* - Vaginal candidiasis usually presents with a **thick, white, cottage cheese-like discharge** accompanied by intense itching and burning. - The patient's description of discharge is simply "profuse," without these specific characteristics.

Q: The K nail can be used for all of the following types of fractures except -

Intertrochanteric fractures. ***Intertrochanteric fractures*** - The K nail (specifically, the Kuntscher nail) is a **straight intramedullary nail** primarily designed for diaphyseal fractures. - It is **not suitable for intertrochanteric fractures** as these are metaphyseal and involve the proximal femur, requiring implants that offer greater stability in this region, such as cephalomedullary nails or plates. *Isthmic femur shaft fractures* - The **Kuntscher nail** was originally developed for and is well-suited for **isthmic femur shaft fractures** due to the narrow canal providing good cortical fixation. - Its design as a straight, broad nail fits snugly in the isthmus, providing excellent stability. *Low subtrochanteric fractures* - While more challenging, **K nails can be used for low subtrochanteric fractures**, especially if the fracture extends into the diaphyseal region. - However, newer implants like **cephalomedullary nails** are often preferred due to better biomechanical stability in this region. *Distal femur shaft fractures* - **K nails can be employed for distal femoral shaft fractures** if the fracture pattern allows for adequate fixation distal to the isthmus without compromising knee joint function. - The nail must be long enough to achieve stability, and the lack of proper locking mechanisms in traditional K nails may be a limiting factor compared to locked intramedullary nails.

Q: Which nerve is primarily affected by lunate dislocation in the carpal tunnel?

Median nerve. ***Median nerve*** - The **lunate bone** dislocates volarly into the **carpal tunnel**, directly compressing the median nerve which passes through this space. - This compression leads to symptoms typical of **carpal tunnel syndrome**, such as numbness and tingling in the thumb, index, middle, and radial half of the ring finger. *Ulnar* - The **ulnar nerve** passes outside the carpal tunnel, through Guyon's canal, and is therefore not typically affected by injuries within the carpal tunnel itself. - Compression of the ulnar nerve would result in symptoms in the little finger and ulnar half of the ring finger, which are not the primary symptoms associated with lunate dislocation. *Radial nerve* - The **radial nerve** primarily innervates the dorsal aspect of the hand and travels more superficially in the forearm, not through the carpal tunnel. - Injuries to the radial nerve usually result from fractures of the humerus or direct trauma to the forearm, not lunate dislocation. *Median & ulnar nerve* - While both nerves can be affected by severe, generalized trauma to the wrist, a classic lunate dislocation specifically targets the **median nerve** within the carpal tunnel. - Concurrent ulnar nerve involvement is less common and would suggest additional or more extensive injury beyond a simple lunate dislocation affecting the carpal tunnel.

Q: What is the mechanism of action of duloxetine?

Inhibition of both serotonin and norepinephrine reuptake. ***Inhibition of both serotonin and norepinephrine reuptake*** - **Duloxetine** is a **serotonin-norepinephrine reuptake inhibitor (SNRI)**, meaning it blocks the reuptake of both neurotransmitters, increasing their concentrations in the synaptic cleft [2]. - This dual action contributes to its efficacy in treating **depression**, **anxiety disorders**, and **neuropathic pain** [2], [3]. *Selective serotonin reuptake inhibition* - This describes the mechanism of **SSRIs (Selective Serotonin Reuptake Inhibitors)**, such as fluoxetine or sertraline, which primarily target serotonin [1]. - Duloxetine's mechanism is broader, affecting both serotonin and norepinephrine [2]. *Selective norepinephrine reuptake inhibition* - This mechanism is characteristic of medications like **atomoxetine**, used for ADHD, which primarily targets norepinephrine. - Duloxetine has a dual action, not selective to norepinephrine alone. *No effect on neurotransmitter reuptake* - Medications with no effect on neurotransmitter reuptake would not typically be effective as antidepressants or treatments for neuropathic pain. - Duloxetine's therapeutic effects are directly linked to its inhibition of reuptake for both serotonin and norepinephrine [2], [4].

Q: Gamma waves of REM sleep are associated with?

Subconscious processing. ***Subconscious processing*** - **Gamma waves (30-100 Hz)** during **REM sleep** represent high-frequency neural oscillations associated with **complex cognitive processing** occurring below the level of conscious awareness. - These waves reflect **integration of neural activity** across different brain regions, facilitating information processing and neural plasticity during sleep. - The term encompasses the underlying **neural mechanisms** that support dream generation and memory consolidation processes. *Dream consciousness and memory consolidation* - While **gamma waves** do correlate with dreaming and memory processes during **REM sleep**, these represent the **experiential and functional outcomes** rather than the primary neurophysiological association. - Dream consciousness is a **manifestation** of the underlying subconscious processing, not the direct association with gamma wave activity itself. *Deep subconscious processing* - The term "deep subconscious" is **non-specific** and lacks precise neurophysiological definition in the context of gamma wave activity. - While directionally correct, this option uses imprecise terminology compared to the more accurate "subconscious processing." *Non-REM sleep* - **Gamma waves** are characteristic of **waking states** and **REM sleep**, not non-REM sleep stages. - **Non-REM sleep** (stages N1, N2, N3) is dominated by **slower wave activity** including theta waves (stage N1), sleep spindles and K-complexes (stage N2), and delta waves (stage N3/deep sleep).

Q: On CT chest, the 'halo sign' is particularly associated with which condition in immunocompromised patients?

Invasive pulmonary aspergillosis. ***Invasive pulmonary aspergillosis*** - The **halo sign** on CT chest, characterized by a ground-glass opacity surrounding a nodule, is a classic radiographic finding in **invasive pulmonary aspergillosis**, especially in immunocompromised patients. - This sign represents hemorrhage around the fungal nodule and indicates active tissue invasion by *Aspergillus* species. *Pulmonary hydatid cyst* - Hydatid cysts are typically well-defined, thin-walled cystic lesions, often displaying the **water lily sign** if complicated by rupture, which is different from the halo sign. - These cysts are caused by the larval stage of *Echinococcus granulosus* and are not associated with a peripheral ground-glass opacity. *Round pneumonia* - Round pneumonia is a localized, **spherical consolidation** often seen in children, which does not typically exhibit the perilesional ground-glass opacity characteristic of the halo sign. - It usually represents bacterial infection and resolves with antibiotics, unlike the invasive fungal disease suggested by the halo sign. *Bronchiectasis* - Bronchiectasis is characterized by **irreversible dilation of the bronchi**, often appearing as "tram-track" opacities or "signet ring" signs on CT. - It is a chronic condition related to airway damage and mucus retention, and not associated with acute nodular lesions or the halo sign.

Q: A 22 year old woman comes with a non progressive mass in the left breast since 6 months. There are no associated symptoms. Examination shows a mobile mass not attached to the overlying skin or underlying tissue. The possible diagnosis is

Fibroadenoma. ***Fibroadenoma*** - This is the most common benign breast tumor in young women, typically presenting as a **mobile, non-tender, firm mass** with no attachment to surrounding tissues. - The history of a **non-progressive mass** over six months in a 22-year-old woman is highly characteristic of a fibroadenoma. *Cystasarcoma Phylloides* - While it can present as a mobile mass, phyllodes tumors tend to grow **rapidly** and can reach a large size, which contradicts the "non-progressive" nature of the mass described. - Phyllodes tumors often have a **leaf-like architectural pattern** histologically and can be benign, borderline, or malignant. *Scirrhous Carcinoma* - This is a type of invasive ductal carcinoma that typically presents as a **hard, irregular, fixed mass** that is often attached to the skin or underlying tissue, unlike the mobile mass described here. - It is common in older women and often associated with **skin dimpling** or nipple retraction. *Fibroadenosis* - This refers to a group of benign breast changes, often presenting with generalized **lumpiness, pain, or tenderness** that fluctuates with the menstrual cycle, rather than a discrete, solitary mass. - It usually presents as **multiple, diffuse nodules** rather than a single, well-defined mass.

Question 1

Dermatitis may be a clinical manifestation of deficiency states of all of the following nutrients except -

Accepted Answer

Thiamine

Answer

Biotin

Answer

Niacin

Answer

Pyridoxine

Question 2

What do the Lines of Blaschko represent?

Accepted Answer

Patterns of cell migration

Answer

Patterns along lymphatics

Answer

Patterns along blood vessels

Answer

Patterns along nerves

Question 3

Following delivery, a tear involving the perineum and external anal sphincter with intact mucosa is classified as which grade?

Accepted Answer

Third degree

Answer

First degree

Answer

Second degree

Answer

Fourth degree

Question 4

A 28-year-old primigravida with 32 weeks of gestation presents with profuse vaginal discharge since yesterday. She was advised USG, which showed a single live intrauterine gestational sac with FL and AC corresponding to the weeks of gestation and AFI as adequate. What is the diagnosis?

Accepted Answer

Normal vaginal discharge

Answer

Candidiasis

Answer

Trichomoniasis

Answer

Preterm Premature Rupture of Membranes (PPROM)

Question 5

The K nail can be used for all of the following types of fractures except -

Accepted Answer

Intertrochanteric fractures

Answer

Isthmic femur shaft fractures

Answer

Low subtrochanteric fractures

Answer

Distal femur shaft fractures

Question 6

Which nerve is primarily affected by lunate dislocation in the carpal tunnel?

Accepted Answer

Median nerve

Answer

Ulnar

Answer

Radial nerve

Answer

Median & ulnar nerve

Question 7

What is the mechanism of action of duloxetine?

Accepted Answer

Inhibition of both serotonin and norepinephrine reuptake

Answer

Selective serotonin reuptake inhibition

Answer

Selective norepinephrine reuptake inhibition

Answer

No effect on neurotransmitter reuptake

Question 8

Gamma waves of REM sleep are associated with?

Accepted Answer

Subconscious processing

Answer

Dream consciousness and memory consolidation

Answer

Deep subconscious processing

Answer

Non-REM sleep

Question 9

On CT chest, the 'halo sign' is particularly associated with which condition in immunocompromised patients?

Accepted Answer

Invasive pulmonary aspergillosis

Answer

Pulmonary hydatid cyst

Answer

Round pneumonia

Answer

Bronchiectasis

Question 10

A 22 year old woman comes with a non progressive mass in the left breast since 6 months. There are no associated symptoms. Examination shows a mobile mass not attached to the overlying skin or underlying tissue. The possible diagnosis is

Accepted Answer

Fibroadenoma

Answer

Cystasarcoma Phylloides

Answer

Scirrhous Carcinoma

Answer

Fibroadenosis

NEET-PG 2015

Biochemistry

Dermatology

Obstetrics and Gynecology

Orthopaedics

Pharmacology

Physiology

Radiology

Surgery