Most common antigen involved in erythroblastosis fetalis is:
Which is not a risk factor for gestational hypertension
Which of the following precancerous conditions, if treated, has the highest likelihood of not leading to cancer?
What does the term 'crowning' refer to in the context of childbirth?
Common misdiagnosis of partial mole is
Lovset manoeuvre is used in delivery of:
Which of the following conditions can lead to a prolonged second stage of labor?
When the fetus is at station +2 and the fetal skull reaches the pelvic floor, which of the following statements is MOST clinically relevant?
Which is false about stress urinary incontinence?
In which part of the fallopian tube is ectopic pregnancy most likely to survive longer?
NEET-PG 2015 - Obstetrics and Gynecology NEET-PG Practice Questions and MCQs
Question 11: Most common antigen involved in erythroblastosis fetalis is:
- A. C antigen in Rh group
- B. E antigen in Rh group
- C. Duffy antigen
- D. D antigen in Rh group (Correct Answer)
Explanation: ***D antigen in Rh group*** - The **D antigen** is the most immunogenic of the Rh antigens and is responsible for the vast majority of cases of **erythroblastosis fetalis** (hemolytic disease of the fetus and newborn). - When an **Rh-negative mother** is exposed to Rh-positive fetal blood (usually during previous pregnancies or transfusions), she can form antibodies against the D antigen, which can then cross the placenta in subsequent pregnancies and attack Rh-positive fetal red blood cells. *C antigen in Rh group* - While the **C antigen** is part of the Rh blood group system, antibodies to it are much less common and typically cause less severe hemolytic disease compared to anti-D antibodies. - The C antigen is less immunogenic than the D antigen, meaning it is less likely to provoke an immune response in an Rh-negative individual. *E antigen in Rh group* - Similar to the C antigen, the **E antigen** is another Rh antigen, but antibodies against it (anti-E) are also less frequently implicated in severe erythroblastosis fetalis than anti-D. - Antibodies to E can cause hemolytic disease, but their clinical significance is usually milder than that of anti-D. *Duffy antigen* - The **Duffy antigen system** is separate from the Rh system and is known for its role in resistance to certain malarial parasites (e.g., *Plasmodium vivax*). - Although antibodies to Duffy antigens (anti-Fya, anti-Fyb) can cause **hemolytic disease of the fetus/newborn**, they are a far less common cause of erythroblastosis fetalis than antibodies to the Rh D antigen.
Question 12: Which is not a risk factor for gestational hypertension
- A. Primigravida
- B. Factor V Leiden mutation
- C. Smoking (Correct Answer)
- D. Low maternal age
Explanation: ***Smoking*** - **Smoking** paradoxically shows a *protective effect* against gestational hypertension and preeclampsia, making it the correct answer as it is NOT a risk factor for gestational hypertension. - This well-documented phenomenon may be related to smoking's vasodilatory effects and reduced production of anti-angiogenic factors. - However, smoking carries numerous other serious risks including **intrauterine growth restriction (IUGR)**, **placental abruption**, **preterm birth**, and **perinatal mortality**. *Primigravida* - **Primigravida** (first pregnancy) is a well-established risk factor for gestational hypertension and preeclampsia. - First-time exposure to paternal antigens and incomplete immune tolerance may contribute to this increased risk. - The risk decreases in subsequent pregnancies with the same partner. *Factor V Leiden mutation* - The **Factor V Leiden mutation** is the most common inherited thrombophilia and significantly increases the risk of gestational hypertension and preeclampsia. - This mutation causes resistance to activated protein C, leading to a hypercoagulable state that can impair placental perfusion. - Associated with increased risk of venous thromboembolism during pregnancy. *Low maternal age* - **Low maternal age** (adolescent pregnancy, <20 years) is actually a recognized *risk factor* for gestational hypertension. - Young mothers may have incomplete physical and cardiovascular maturity to handle pregnancy-related physiological changes. - Adolescent pregnancies are associated with higher rates of hypertensive disorders of pregnancy.
Question 13: Which of the following precancerous conditions, if treated, has the highest likelihood of not leading to cancer?
- A. Cervical intraepithelial Neoplasia (Correct Answer)
- B. Ductal carcinoma in situ of breast
- C. Lobular carcinoma in situ of breast
- D. Vaginal intraepithelial neoplasia
Explanation: ***Cervical intraepithelial neoplasia (CIN)*** - CIN has a high success rate with treatment (e.g., **cryotherapy**, **LEEP**), often completely eradicating the dysplastic cells and preventing progression to **invasive cervical cancer**. - The effectiveness of screening via **Pap smears** allows for early detection and intervention, significantly reducing cancer risk. *Ductal carcinoma in situ (DCIS) of breast* - While treatable, DCIS carries a higher risk of recurrence and progression to **invasive breast cancer** in the same or contralateral breast compared to CIN. - Treatment often involves **lumpectomy** with or without radiation, and sometimes **total mastectomy**, reflecting its more serious potential. *Lobular carcinoma in situ (LCIS) of breast* - LCIS is largely considered a **risk indicator** for future invasive cancer in either breast, rather than a direct precursor that inevitably progresses. - Management often involves **close surveillance** or **chemoprevention**, as surgical excision does not prevent cancer development in other areas of the breast. *Vaginal intraepithelial neoplasia (VAIN)* - While treatable, VAIN is less common and often coexists with or follows **cervical or vulvar neoplasia**, indicating a broader field defect due to **HPV**. - Recurrence rates post-treatment can be significant, and patients often require long-term follow-up due to the continued risk of progression.
Question 14: What does the term 'crowning' refer to in the context of childbirth?
- A. Biparietal diameter at the inlet of pelvis
- B. Biparietal diameter at the ischial spine
- C. Biparietal diameter just outside the vulval outlet
- D. Biparietal diameter at the vulval outlet (Correct Answer)
Explanation: ***Biparietal diameter at the vulval outlet*** - **Crowning** specifically refers to the moment when the largest diameter of the baby's head (the **biparietal diameter**) has passed through the pelvic outlet and becomes visible at the vaginal opening without receding between contractions. - This signifies that the head is fully engaged and will no longer slip back, making birth imminent. *Biparietal diameter at the inlet of pelvis* - The **biparietal diameter** at the inlet of the pelvis describes the initial engagement of the fetal head into the pelvis, which is a much earlier stage than crowning. - This stage is referred to as **engagement**, not crowning, and there is no visible head at this point. *Biparietal diameter at the ischial spine* - The **ischial spines** are a landmark often used to assess the fetal head's station in the pelvis (how far down it has descended). - While important for assessing progress, the biparietal diameter reaching the ischial spines indicates a **station 0**, which is still internal and not visible at the vulva, thus not crowning. *Biparietal diameter just outside the vulval outlet* - If the **biparietal diameter** is **just outside** the vulval outlet, it implies the head has already been born or is so far progressed that crowning has already occurred or the head is delivering. - Crowning specifically describes the moment it becomes visible and sustained at the outlet, not outside it.
Question 15: Common misdiagnosis of partial mole is
- A. Choriocarcinoma
- B. Complete mole
- C. Ectopic pregnancy
- D. Threatened abortion (Correct Answer)
Explanation: ***Threatened abortion*** - Partial moles often present with **vaginal bleeding** and a uterus size appropriate for gestational age, mimicking the symptoms of a **threatened abortion**. - **Fetal heartbeat** may be detectable in a partial mole, further complicating differentiation from a threatened abortion without detailed ultrasound or histological examination. *Choriocarcinoma* - **Choriocarcinoma** is a malignant tumor and a complication of molar pregnancy, not a common misdiagnosis of an early partial mole. - While both involve abnormal trophoblastic tissue, **choriocarcinoma** follows a molar pregnancy (or other gestations) and presents with systemic symptoms and very high hCG levels, distinct from the initial presentation of a partial mole. *Complete mole* - **Complete moles** are distinct from partial moles both genetically (46,XX or 46,XY with paternal origin only) and pathologically (no fetal tissue, generalized hydropic villi). - While both are types of molar pregnancy, they have different management and prognostic implications, and are distinct entities rather than a misdiagnosis of one for the other's initial presentation. *Ectopic pregnancy* - An **ectopic pregnancy** typically presents with pain and vaginal bleeding, along with an empty uterus on ultrasound. - While both involve abnormal pregnancy presentations, a **partial mole** usually shows some fetal tissue or identifiable placental tissue within the uterine cavity, distinguishing it from an ectopic pregnancy.
Question 16: Lovset manoeuvre is used in delivery of:
- A. Arms (Correct Answer)
- B. Head
- C. Breech
- D. Foot
Explanation: ***Arms*** - The Lovset manoeuvre is specifically designed to facilitate the delivery of the **shoulders and arms** in a **breech presentation** when they are extended upwards. - This technique involves rotating the fetal trunk to bring the anterior shoulder under the pubic symphysis, allowing for the gentle extraction of the posterior arm first, followed by the anterior arm. *Head* - Delivery of the head in a breech presentation is typically managed using **Mauriceau-Smellie-Veit manoeuvre** or Piper forceps, not the Lovset manoeuvre. - The Lovset manoeuvre aims to address difficult arm delivery prior to head delivery. *Breech* - While the Lovset manoeuvre is used *during* a breech delivery, it specifically addresses **arm extraction**, not the overall delivery of the entire breech presentation. - The term "breech" refers to the fetal presentation where the buttocks or feet are presented first. *Foot* - If a foot is presenting first, it is usually a **footling breech presentation**, and the delivery of the foot itself does not typically require the Lovset manoeuvre. - The Lovset manoeuvre is reserved for extended arms, which are distinct from the initial presentation of a foot.
Question 17: Which of the following conditions can lead to a prolonged second stage of labor?
- A. Cephalopelvic disproportion
- B. All of the options (Correct Answer)
- C. Uterine inertia
- D. Maternal exhaustion
Explanation: ***All of the options*** - **Uterine inertia**, **maternal exhaustion**, and **cephalopelvic disproportion** are all well-established causes of a prolonged second stage of labor. - These factors either impede effective uterine contractions, reduce the mother's ability to push, or create a physical barrier to fetal descent, respectively. *Uterine inertia* - Refers to **weak** or **ineffective uterine contractions** that are insufficient to expel the fetus. - This directly prolongs the second stage by failing to provide adequate propulsive force. *Maternal exhaustion* - Occurs when the mother becomes too **tired** to effectively push, often due to a long and difficult labor. - Reduced maternal effort leads to a lack of downward pressure, extending the second stage. *Cephalopelvic disproportion* - Characterized by a mismatch between the **size of the fetal head** and the **maternal pelvis**, preventing the head from descending. - This mechanical obstruction inevitably leads to a prolonged, and often ultimately arrested, second stage of labor.
Question 18: When the fetus is at station +2 and the fetal skull reaches the pelvic floor, which of the following statements is MOST clinically relevant?
- A. Forceps may be applied if necessary. (Correct Answer)
- B. Crowning occurs at this stage.
- C. There is a risk of deep transverse arrest.
- D. Episiotomy must be performed at this station.
Explanation: ***Forceps may be applied if necessary.*** - At **station +2**, the fetal head has progressed significantly into the pelvis (2 cm below the ischial spines), indicating a **low-lying head** where instrumental delivery with **forceps** or a **vacuum extractor** can be safely performed if indicated (e.g., maternal exhaustion, fetal distress). - This station qualifies as **low forceps** or **outlet forceps** delivery, which are considered safe procedures when properly indicated. - The fetal head at this level has reached or is approaching the **pelvic floor**, meeting the prerequisites for assisted vaginal delivery. *Crowning occurs at this stage.* - **Crowning** specifically refers to the stage when the largest diameter of the fetal head is visible at the **vaginal introitus** and does not recede between contractions. - This occurs at approximately **station +4 to +5**, not at station +2. - While station +2 indicates significant descent, the fetus must descend further before crowning occurs. *There is a risk of deep transverse arrest.* - **Deep transverse arrest** occurs when the fetal head fails to internally rotate from the transverse position to an occipito-anterior or occipito-posterior position. - This complication typically occurs at **station 0 to +1** (mid-pelvis level), not at station +2. - By the time the fetal head reaches station +2 and the pelvic floor, internal rotation should have already occurred. *Episiotomy must be performed at this station.* - **Episiotomy** is **not mandatory** at any particular fetal station. - It is a selective procedure performed when indicated, typically just before crowning (around station +3 to +4), to prevent severe perineal trauma or expedite delivery. - The decision is based on clinical factors like fetal size, maternal tissue quality, and risk of severe laceration—not solely on fetal station.
Question 19: Which is false about stress urinary incontinence?
- A. More common in men (Correct Answer)
- B. It is due to weakening of pelvic floor muscles
- C. Prostate surgery may be a cause
- D. It occurs during increased abdominal pressure
Explanation: ***More common in men*** - **Stress urinary incontinence (SUI)** is significantly more prevalent in **women** due to anatomical differences and factors like childbirth. - While it can occur in men, especially after prostate surgery, the overall incidence is higher in females. *It is due to weakening of pelvic floor muscles* - Weakening of the **pelvic floor muscles** is a primary cause of SUI, leading to insufficient support for the urethra and bladder neck. - This weakness compromises the ability to maintain urethral closure pressure during activity. *Prostate surgery may be a cause* - **Radical prostatectomy** for prostate cancer is a common cause of SUI in men, as it can damage the urethral sphincter. - Damage to the internal or external urethral sphincter during surgery impairs the ability to control urine flow. *It occurs during increased abdominal pressure* - SUI characteristically involves involuntary urine leakage during activities that increase **intra-abdominal pressure**, such as coughing, sneezing, laughing, or exercising. - This increased pressure overcomes the weakened urethral resistance, leading to urine loss.
Question 20: In which part of the fallopian tube is ectopic pregnancy most likely to survive longer?
- A. Isthmus
- B. Ampulla
- C. Cornua
- D. Interstitial (Correct Answer)
Explanation: ***Interstitial*** - An **interstitial (intramural) pregnancy** occurs in the portion of the fallopian tube that passes through the muscular wall of the uterus, known as the **cornua**. This position allows for a larger and more distensible space, potentially accommodating the pregnancy for a longer duration before rupture. - The surrounding **myometrial tissue** can provide a temporary blood supply and structural support, leading to later presentation (often up to 12-16 weeks) and often more significant hemorrhage upon rupture due to the rich vascularization of the uterine wall. - Interstitial pregnancies account for approximately 2-4% of all ectopic pregnancies but have a higher mortality rate due to massive hemorrhage when rupture occurs. *Isthmus* - The **isthmus** is the narrowest part of the fallopian tube, making it less accommodating for an ectopic pregnancy. - Pregnancies here tend to rupture earlier (typically by 6-8 weeks) due to limited space and thinner muscular walls. - Accounts for approximately 12% of tubal ectopic pregnancies. *Ampulla* - The **ampulla** is the most common site for ectopic pregnancies (approximately 70-80%), but pregnancies here typically rupture earlier than interstitial ones (usually by 8-12 weeks). - While wider than the isthmus, it lacks the substantial myometrial support of the interstitial portion. - The ampullary wall is thin and distensible but cannot sustain pregnancy as long as the interstitial portion. *Cornua* - While the interstitial part of the tube is located within the uterine wall (cornua), \"cornua\" itself refers to the upper angles of the uterus where the fallopian tubes enter. - The term **\"cornual pregnancy\"** is sometimes used interchangeably with **\"interstitial pregnancy,\"** though some authorities distinguish between them based on precise location. - Without the specific context of \"interstitial,\" this option is less precise in identifying the segment of the fallopian tube associated with prolonged survival.