Question 1: Which of the following syndromes is least likely to be associated with obesity?
- A. Cushing syndrome
- B. Prader willi syndrome
- C. Sipple syndrome (Correct Answer)
- D. Pickwickian syndrome
Explanation: ***Sipple syndrome***
- Sipple syndrome, also known as **multiple endocrine neoplasia type 2**, is primarily associated with **medullary thyroid carcinoma** and does not typically correlate with obesity.
- It includes signs like **pheochromocytoma** and **hyperparathyroidism**, but obesity is not a prominent feature.
*Cushing syndrome*
- Cushing syndrome leads to **excess cortisol**, commonly resulting in weight gain and central obesity [1].
- Characteristic features include **moon facies**, **buffalo hump**, and easy bruising, all associated with obesity [1].
*Pickwinian syndrome*
- Pickwinian syndrome, characterized by **severe obesity**, is a condition primarily affecting physical stature and weight.
- It is linked to **hypoventilation** and sleep apnea, reinforcing the presence of obesity.
*Prader willi syndrome*
- Prader-Willi syndrome is marked by **insatiable hunger** leading to **obesity** due to hypothalamic dysfunction [2].
- Individuals with this condition also demonstrate **hypotonia** and developmental delays, commonly accompanied by obesity [2].
**References:**
[1] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. The Endocrine System, pp. 1127-1129.
[2] Kumar V, Abbas AK, et al.. Robbins and Cotran Pathologic Basis of Disease. 9th ed. Central Nervous System Synapse, pp. 454-455.