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INI-CET 2012 — Physiology

Q: At what temperature does heat stiffening occur in the body?

> 60°C. ***> 60°C*** - **Heat stiffening**, or **heat rigor**, primarily results from the **coagulation of muscle proteins** and occurs at temperatures significantly above physiological ranges [1]. - At temperatures exceeding **60-65°C**, proteins begin to denature irreversibly, leading to macroscopic stiffening of tissues [1]. *30°C* - This temperature is within the normal physiological range or slightly below it; **hypothermia** can occur, but not heat stiffening. - Muscle function may be impaired, leading to **shivering or reduced coordination**, but not the structural changes associated with heat rigor. *40°C* - This temperature represents a **moderate fever** or **mild hyperthermia**, which can cause discomfort, but does not induce tissue stiffening [3]. - While metabolic processes are affected, **protein denaturation** leading to rigor does not occur at this level. *50°C* - Exposure to 50°C can cause significant **tissue damage** and **burns**, but direct **heat stiffening** requires higher temperatures for widespread protein coagulation. - At this temperature, cellular damage, including enzyme denaturation, begins to be severe, but full body rigor is not typically observed [2]. [Practice more Physiology PYQs on OnCourse]

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At what temperature does heat stiffening occur in the body?