INI-CET 2012 — Microbiology

Question 1: Which of the following is the aetiological agent most often associated with Epiglottitis in children -

• A. Neisseria sp
• B. Moraxella catarrhalis
• C. Haemophilus influenzae type b (Correct Answer)
• D. Streptococcus pneumoniae

Explanation: ***Haemophilus influenzae type b*** - Historically, **_Haemophilus influenzae_ type b (Hib)** was the most common cause of **epiglottitis** in children. - The introduction of the **Hib vaccine** has significantly reduced its incidence, but it remains a crucial consideration. *Neisseria sp* - **_Neisseria_ species** are typically associated with infections like **meningitis** and **gonorrhea**, not primary causes of epiglottitis. - While **_Neisseria meningitidis_** can cause invasive disease, it's not a common pathogen for epiglottitis. *Moraxella catarrhalis* - **_Moraxella catarrhalis_** is a common cause of **otitis media**, **sinusitis**, and **bronchitis**, especially in children. - It is not a principal cause of acute epiglottitis. *Streptococcus pneumoniae* - **_Streptococcus pneumoniae_** is a major cause of **pneumonia**, **otitis media**, **meningitis**, and **sepsis**. - While it can cause respiratory infections, it is not the most frequent pathogen associated with epiglottitis compared to Hib pre-vaccine era.