Quick Overview
Normal growth and development assessment is fundamental to paediatric practice. Understanding centile charts, developmental milestones, and red flags enables early detection of pathology. NICE NG143 provides evidence-based thresholds for investigating faltering growth (previously "failure to thrive"), emphasizing when clinical concern should trigger investigation versus watchful waiting.
Core Facts & Concepts
📊 Growth Monitoring:
- Centile interpretation: Plot on UK-WHO charts (0-4y) or UK90 (4-20y)
- Concerning patterns:
- Crossing ≥2 centile spaces downward (faltering growth)
- Crossing ≥3 centile spaces upward (rapid/excessive growth)
- Weight <2nd centile or >98th centile
- Growth velocity: Calculate cm/year; normal 5-7cm/year ages 3-10y, then pubertal acceleration 8-14cm/year

🎯 Key Developmental Milestones:
| Age | Gross Motor | Fine Motor/Vision | Speech/Hearing | Social |
|---|---|---|---|---|
| 6 weeks | Head lag reducing | Fixes and follows | Startles to sound | Social smile |
| 6 months | Sits with support | Palmar grasp, reaches | Babbles | Stranger awareness |
| 12 months | Walks with 1 hand held | Pincer grip | 2-3 words with meaning | Waves bye-bye |
| 18 months | Walks independently | Tower of 3 cubes | 6-10 words | Feeds with spoon |
| 2 years | Runs, kicks ball | Tower of 6 cubes | 50+ words, 2-word phrases | Parallel play |
| 3 years | Climbs stairs alternating feet | Copies circle | 3-word sentences | Symbolic play |
| 4 years | Hops on one foot | Copies cross | Asks questions | Cooperative play |
⚠️ NICE NG143 Faltering Growth Thresholds:
- Investigate if: Weight crosses ≥2 centile spaces + clinical concern (feeding difficulties, developmental delay, parental anxiety)
- Don't investigate if: Thriving child with normal development, no safeguarding concerns
Problem-Solving Approach
🚩 Red Flags for Developmental Delay:
- Any age: Loss of previously acquired skills (regression)
- 6 months: No social smile, persistent primitive reflexes
- 12 months: Not sitting independently, no babble
- 18 months: Not walking independently, <6 words
- 2 years: No 2-word phrases, not running
- Asymmetry: Hand preference <12 months (suggests hemiplegia)

📋 Faltering Growth Investigation Pathway (NICE NG143):
- History: Feeding pattern, dietary intake (3-day diary), symptoms (vomiting, diarrhoea), family/social factors
- Examination: Plot all parameters, dysmorphic features, systemic examination, safeguarding assessment
- First-line tests (if indicated):
- FBC (anaemia, infection)
- Coeliac serology (tissue transglutaminase IgA + total IgA)
- U&E, creatinine (renal disease)
- Consider: Urinalysis, thyroid function
- Refer if: Suspected organic disease, safeguarding concerns, inadequate response to management
⭐ Clinical Pearl: Most faltering growth is non-organic (inadequate intake, psychosocial factors). Investigate when clinical features suggest organic cause or safeguarding risk.
Analysis Framework
🔍 Faltering Growth Differential:
| Category | Key Features | Examples |
|---|---|---|
| Inadequate intake (most common) | Poor feeding technique, psychosocial stress | Poverty, parental mental health, feeding aversion |
| Malabsorption | Diarrhoea, abdominal distension | Coeliac disease, cystic fibrosis, cow's milk protein allergy |
| Increased losses | Vomiting, polyuria | GORD, pyloric stenosis, diabetes, renal tubular acidosis |
| Increased requirements | Dyspnoea, tachycardia | Congenital heart disease, chronic infection, hyperthyroidism |
| Failure to utilise | Dysmorphism, developmental delay | Genetic syndromes, metabolic disorders |
Decision Rule: Investigate or Watch?
- Investigate: Clinical concern + centile crossing + symptoms/signs
- Watch: Healthy child, normal development, moving toward mid-parental centile
Visual Aid
Key Points Summary
✓ Faltering growth: Crossing ≥2 centile spaces downward with clinical concern warrants investigation (NICE NG143)
✓ Growth velocity: Normal 5-7cm/year pre-puberty; calculate over ≥6 months for accuracy
✓ Red flag milestones: No social smile 8 weeks, not sitting 12 months, not walking 18 months, no words 18 months
✓ Developmental regression: Loss of skills = urgent neurology referral; always abnormal
✓ Hand preference <12 months: Suggests hemiplegia; investigate neurologically
✓ Most faltering growth is non-organic: Investigate when symptoms/signs suggest organic cause or safeguarding concerns
✓ First-line tests: Coeliac serology, FBC, U&E if investigating faltering growth with clinical concern
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