Hair Follicle & Cycles - Root of the Problem
- Follicle Structure:
- Composed of: Infundibulum, Isthmus, Suprabulbar region, and Bulb.
- Key targets for hair removal: Bulb (contains matrix cells) & Bulge (contains stem cells).
- Hair Growth Cycles: 📌 ACTE (Anagen, Catagen, Telogen, Exogen).
- Anagen (Growth): 85-90% of hairs; active melanin production. Ideal laser target. Duration: Scalp (2-6 yrs), Body (months).
- Catagen (Involution): <1-2%; lasts 2-3 weeks.
- Telogen (Rest): 10-15%; lasts 2-3 months.

⭐ Lasers are most effective during the anagen phase because melanin, the target chromophore, is abundant in the hair bulb and follicle epithelium then.
Temporary Methods - Quick Vanish
- Shaving:
- Cuts hair at skin surface.
- Pros: Rapid, inexpensive.
- Cons: Regrowth 1-3 days (blunt tip), folliculitis, pseudofolliculitis.
- Tweezing/Plucking:
- Pulls hair from root.
- Pros: Lasts 3-8 weeks, precise (small areas).
- Cons: Painful, time-consuming, ingrown hairs, PIH.
- Threading:
- Thread traps & pulls hairs from follicle.
- Pros: Precise (face), lasts 3-6 weeks.
- Cons: Painful, needs skill.
- Depilatory Creams:
- Chemicals (thioglycolates) break keratin bonds.
- Pros: Painless, quick.
- Cons: Regrowth few days-1 week; skin irritation (patch test!).
⭐ Active ingredients: Salts of thioglycolic acid (e.g., potassium/calcium thioglycolate).
- Waxing (Hot/Cold):
- Pulls hair from root with wax.
- Pros: Lasts 3-6 weeks, finer regrowth.
- Cons: Painful, burns (hot), folliculitis, PIH. ⚠️ Avoid with retinoids.
Laser & Light Reduction - Zap Those Follicles!
- Principle: Selective photothermolysis - light energy absorbed by melanin in hair follicle → thermal destruction.
- Targets hair in anagen (active growth) phase. Multiple sessions (6-8) typically needed, 4-8 weeks apart.
- Common Lasers & Light Sources:
- Alexandrite (755 nm): For fair skin (Fitzpatrick I-III). Fast. High melanin absorption.
- Diode (800-810 nm): Effective for Indian skin (Fitzpatrick III-V). Good balance.
- Nd:YAG (Long-pulsed 1064 nm): Safest for dark/tanned skin (Fitzpatrick IV-VI). Deepest penetration, lower epidermal melanin absorption.
- Intense Pulsed Light (IPL): Broad spectrum (e.g., 500-1200 nm). Uses filters. Versatile, less specific.
- Key Parameters:
- Wavelength (nm): Determines depth & target. Longer λ → deeper penetration.
- Fluence (J/cm²): Energy density. Key for efficacy/safety.
- Pulse Duration (ms): ≤ Thermal Relaxation Time (TRT) of the target follicle.
- Spot Size (mm): Larger spot → deeper penetration & faster treatment.
- Epidermal Cooling: Essential (contact, cryogen spray, cold air) to protect epidermis, esp. in darker skin.
- Side Effects:
- Common: Transient pain, erythema, perifollicular edema.
- Potential: Burns, blisters, pigmentary changes (hypo/hyper, esp. with incorrect parameters in darker skin), paradoxical hypertrichosis (rare, esp. face/neck, often with low fluence).
- Pre-care: Avoid sun exposure, tanning, plucking/threading/waxing for 4-6 weeks. Shaving OK.
- Post-care: Strict sun protection, emollients.

⭐ Long-pulsed Nd:YAG (1064 nm) is preferred for Indian skin (Fitzpatrick IV-VI) due to deep penetration & lower epidermal melanin absorption, minimizing pigmentary side effects.
Electrolysis & Medical Rx - Needle & Prescription
- Electrolysis: Permanent hair removal; needle probe destroys follicle.
- Galvanic: Chemical (lye via DC current). Slow, effective.
- Thermolysis (Diathermy): Heat (AC current). Faster.
- Blend: Combines galvanic & thermolysis. Good efficacy, faster than galvanic.
- Medical Rx (Topical):
- Eflornithine HCl 13.9% cream (Vaniqa): Irreversible ornithine decarboxylase inhibitor. Slows facial hair growth. Apply BID.
⭐ Eflornithine is FDA-approved for unwanted facial hair in women; results visible in 4-8 weeks but requires continued use as it's not depilatory or curative (does not remove hair permanently).
- Eflornithine HCl 13.9% cream (Vaniqa): Irreversible ornithine decarboxylase inhibitor. Slows facial hair growth. Apply BID.
High‑Yield Points - ⚡ Biggest Takeaways
- Laser Hair Removal (LHR) targets melanin; best for dark hair, light skin.
- Nd:YAG laser (1064 nm) is safer for darker skin types (Fitzpatrick IV-VI).
- Electrolysis is the only FDA-approved permanent hair removal method.
- Eflornithine HCl topically inhibits ornithine decarboxylase, reducing facial hair.
- Intense Pulsed Light (IPL) uses broad-spectrum light, less specific than lasers.
- Optimal target for light methods: hair in anagen (growth) phase.
- Risks: pigmentary changes, burns, paradoxical hypertrichosis (especially with low fluences).
Continue reading on Oncourse
Sign up for free to access the full lesson, plus unlimited questions, flashcards, AI-powered notes, and more.
CONTINUE READING — FREEor get the app