Liver, Gallbladder and Biliary Tract

Liver, Gallbladder and Biliary Tract

Liver, Gallbladder and Biliary Tract

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Liver Anatomy - The Body's Powerhouse

Largest gland (~1.5 kg); RUQ, under diaphragm. Gross anatomy of the liver

  • Lobes & Segments:
    • Anatomical: Right, Left, Caudate, Quadrate.
    • Functional: 8 Couinaud segments (key for resections); Cantlie's line divides.
  • Coverings: Glisson's capsule; Peritoneum (except bare area).
  • Ligaments: Falciform, Coronary, Triangular, Lig. teres hepatis (obliterated umbilical vein), Lig. venosum.
  • Blood Supply (Dual):
    • Portal Vein: ~75% inflow (nutrient-rich).
    • Hepatic Artery: ~25% inflow (oxygenated).
    • Drainage: Hepatic veins → IVC.
  • Porta Hepatis: Gateway for portal triad (hepatic artery, portal vein, bile duct). 📌 Mnemonic: "PAD"

⭐ Cantlie's line, from IVC fossa to gallbladder fossa, marks the true functional division of the liver.

Liver Microanatomy - Tiny Titans at Work

  • Hepatic Lobule: Hexagonal; central vein, portal triads at periphery.
  • Portal Triad: Portal vein, hepatic artery, bile duct. (📌 PAB)
  • Hepatocytes: In cords; metabolic, synthetic, detox functions.
  • Sinusoids: Channels with fenestrated endothelium, Kupffer cells (macrophages).
  • Space of Disse: Perisinusoidal; exchange site; Stellate (Ito) cells (Vit A, fibrosis).
  • Acinus (Functional):
    • Zone 1 (Periportal): ↑O₂, viral hepatitis, gluconeogenesis.
    • Zone 3 (Centrilobular): ↓O₂, ischemia, alcohol, P450. Liver lobule and acinus zones

⭐ Zone 3 is most susceptible to ischemic injury and toxic damage due to its poor oxygenation and high concentration of P450 enzymes.

Gallbladder - Bile's Little Buddy

  • Location: Fossa on visceral surface of liver, between quadrate lobe & right lobe.
  • Function: Stores & concentrates bile (capacity 30-50 mL).
  • Parts: Fundus, body, infundibulum (Hartmann's pouch - common site for gallstones), neck.
  • Blood Supply: Cystic artery (usually from right hepatic artery in Calot's triangle).
  • Venous Drainage: Cystic vein → portal vein.
  • Innervation: Vagus (parasympathetic), celiac plexus (sympathetic).

Anatomy of Gallbladder and Calot's Triangle

Calot's Triangle Boundaries: Cystic duct (inferiorly), common hepatic duct (medially), and inferior surface of the liver (superiorly). Contents: Cystic artery, cystic lymph node (of Lund).

Biliary Tract - The Bile Superhighway

  • Bile Flow: Intrahepatic ducts → R/L Hepatic Ducts → Common Hepatic Duct (CHD).
    • CHD joins Cystic Duct (from Gallbladder) → forms Common Bile Duct (CBD).
    • CBD joins Main Pancreatic Duct → Hepatopancreatic Ampulla of Vater → empties into Duodenum via Sphincter of Oddi.
  • Gallbladder: Concentrates & stores bile (capacity 30-50 mL). Cholecystokinin (CCK) triggers release.
  • CBD: Normal diameter ≤ 6 mm (may ↑ to 10 mm post-cholecystectomy or with age).

Biliary system and pancreatic duct diagram

⭐ > Courvoisier's Law: A palpable, non-tender gallbladder with jaundice often indicates periampullary malignancy, not gallstones.

Hepato-Biliary Clinicals - Surgeon's Eye View

  • Jaundice: Differentiate obstructive (surgical) vs. hepatocellular.
  • Gallbladder & Biliary Tree:
    • Cholecystitis: Murphy’s sign, RUQ pain.
    • Cholelithiasis: RUQ pain, fat intolerance.
    • Cholangitis: Charcot’s triad (fever, pain, jaundice); Reynold’s pentad (+ shock, AMS).
    • Calot’s Triangle: For cholecystectomy. Boundaries: Cystic Duct, Common Hepatic Duct, Inf. Liver Edge. 📌 Cystic Artery within.
  • Liver:
    • Portal Hypertension: Varices, ascites.
    • Trauma: Pringle maneuver (↓bleed).
    • Resection: Couinaud segments guide. Calot's triangle and surrounding structures

⭐ Jaundice + palpable, non-tender gallbladder = likely malignancy, not stones (Courvoisier's Law).

High‑Yield Points - ⚡ Biggest Takeaways

  • Cantlie's line demarcates true right/left functional liver lobes.
  • Portal triad (portal vein, hepatic artery, bile duct) is in the hepatoduodenal ligament.
  • The bare area of the liver lacks peritoneal covering, allowing direct contact with the diaphragm.
  • Calot's triangle (cystic duct, common hepatic duct, liver edge) contains the cystic artery.
  • Sphincter of Oddi regulates bile and pancreatic juice flow into the duodenum.
  • Couinaud segments (I-VIII) form the basis for hepatic surgical resections.
  • Hartmann's pouch of the gallbladder is a common site for gallstone impaction.

Practice Questions: Liver, Gallbladder and Biliary Tract

Test your understanding with these related questions

CT scan of abdomen showing a structure branching within the liver. Identify the structure.

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Flashcards: Liver, Gallbladder and Biliary Tract

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The _____ duct and main pancreatic duct join at the ampulla of Vater

TAP TO REVEAL ANSWER

The _____ duct and main pancreatic duct join at the ampulla of Vater

common bile

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