Neurobiological theories of schizophrenia — Flashcards

Flashcard 1: Are typical antipsychotics effective at treating the positive or negative symptoms of schizophrenia? _____

Answer: Positive

Flashcard 2: Schizophrenia is associated with _____ dendritic branching

Answer: decreased

Flashcard 3: Which dopaminergic pathway is the primary target for the antipsychotic treatment of schizophrenia?

Answer: Mesolimbic pathway

Flashcard 4: Schizophrenia is characterized by _____ on CT

Answer: ventriculomegaly

Flashcard 5: Are atypical antipsychotics effective at treating the positive or negative symptoms of schizophrenia? _____

Answer: Both

Flashcard 6: Which neurotransmitter's level is primarily increased in schizophrenia according to the classic hypothesis?

Answer: Increased dopamine levels (Dopamine hypothesis)

Extra: Schizophrenia is primarily associated with increased dopaminergic activity in the mesolimbic pathway (positive symptoms) and decreased activity in the mesocortical pathway (negative symptoms). \n\nOther neurotransmitter changes:\n- Increased Serotonin\n- Decreased Glutamate (via NMDA receptor hypofunction)

Flashcard 7: Are typical antipsychotics effective at treating the positive or negative symptoms of schizophrenia? _____

Answer: Positive

Extra:   Sketchy Pharmacology: Neuro/Psych Watch First generation antipsychotics [https://dashboard.sketchy.com/study/medical/courses/medical-pharmacology/units/medical-pharmacology-neuro-psych/videos/medical-pharmacology-neuropsych-antipsychotics-and-parkinsons-first-generation-antipsychotics?utm_source=anki&utm_medium=partnership&utm_campaign=february_update&utm_content=medical]Watch associated Bootcamp video [https://app.bootcamp.com/med-school/psychiatry/videos/pharmacology?index=14] https://onlinemeded.org/spa/psychiatry?ref=anki 

Flashcard 8: Schizophrenia is associated with _____-creased serotonergic activity and decreased dendritic branching

Answer: in

Extra: Watch associated Bootcamp video [https://app.bootcamp.com/med-school/psychiatry/videos/psychotic-and-mood-disorders?index=10] https://onlinemeded.org/spa/psychiatry?ref=anki 

Flashcard 9: Is the prevalence of schizophrenia more common in a particular race?\n_____

Answer: No

Extra: Schizophrenia prevalence is equal across different races and cultures.

Flashcard 10: Which type of aphasia is characterized by the following: _____ 1. Fluent speech 2. Impaired comprehension 3. Impaired repetition

Answer: Wernicke (receptive) aphasia

Extra:  Watch associated Bootcamp video [https://app.bootcamp.com/med-school/neurology/videos/cerebral-cortext?index=4] https://onlinemeded.org/spa/neurology?ref=anki