Ammonia production and excretion — Flashcards

Flashcard 1: In the lumen of late distal tubule and collecting duct, secreted H+ combines with the HPO4- to form H2PO4, which is a _____ acid

Answer: titratable

Flashcard 2: What acid-base disturbance is associated with hyperkalemia? _____

Answer: Acidosis

Flashcard 3: In the lumen of the collecting duct, NH3 and H+ form NH4+, which is trapped in the tubular fluid and excreted ("_____"))

Answer: diffusion trapping

Flashcard 4: H+ is secreted by _____ on the luminal membrane of the α-intercalated cells of the collecting duct

Answer: H+-ATPase

Flashcard 5: In hyperkalemic RTA, decreased NH3 synthesis in the PCT causes decreased _____ excretion

Answer: NH4+

Flashcard 6: Renal compensation of respiratory alkalosis includes _____ excretion of fixed H+ as titratable acid and NH4+

Answer: decreased

Flashcard 7: Which renal tubular acidosis is associated with increased urinary excretion of HCO3-? _____

Answer: Proximal RTA (type 2)

Flashcard 8: Which acid-base disturbance is caused by increased HCO3-? _____

Answer: Metabolic alkalosis

Flashcard 9: In _____ cells, CO2 is combined with H2O via the enzyme carbonic anhydrase, forming H2CO3

Answer: red blood

Extra: Carbonic anhydrase is located within red blood cells, making this reaction much faster than in plasma.

Flashcard 10: Acid-base disturbances may affect serum K+ levels via altering activity and directionality of the _____ exchanger

Answer: H+-K+

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