Complement inhibitors — Flashcards

Flashcard 1: Eculizumab is a monoclonal antibody for the _____ complement protein

Answer: C5

Flashcard 2: Which antitumor monoclonal antibody can treat vasculitides?_____

Answer: Rituximab

Flashcard 3: Cephalosporins rarely can cause anemia by inducing _____ Bonus: Which cephalosporins are most commonly associated?

Answer: anti-RBC autoantibodies (Immune Hemolytic Anemia) Bonus: Cefotetan and Ceftriaxone

Flashcard 4: What class of drugs are contraindicated in C1 esterase inhibitor deficiency? _____

Answer: ACE inhibitors

Flashcard 5: Eculizumab is indicated for the treatment of _____

Answer: Paroxysmal Nocturnal Hemoglobinuria

Flashcard 6: Paroxysmal nocturnal hemoglobinuria may be treated with _____, which is a terminal complement inhibitor

Answer: eculizumab

Flashcard 7: Which enzyme in the bacterial folate synthesis pathway is inhibited by **Trimethoprim**?

Answer: Dihydrofolate reductase (DHFR)

Extra: Trimethoprim inhibits bacterial dihydrofolate reductase, which prevents the reduction of dihydrofolic acid to tetrahydrofolic acid (THF). Sulfonamides inhibit dihydropteroate synthase, the step immediately preceding this in the folate synthesis pathway.