Thyroid hormone replacements — Flashcards

Flashcard 1: Which thyroid medications are associated with aplastic anemia?_____

Answer: Propylthiouracil (PTU) and methimazole

Flashcard 2: What T3 hormone analog is used to treat hypothyroidism and myxedema?

Answer: Liothyronine

Extra: Levothyroxine is the T4 analog (drug of choice for hypothyroidism). Liothyronine is the T3 analog (faster onset, used in myxedema coma).

Flashcard 3: Beta-blockers (ex propranolol) can block peripheral conversion of T4 into T3 by inhibiting _____

Answer: 5'-deiodinase

Flashcard 4: What is the treatment of choice for a pregnant women with hyperthyroidism in the first trimester?_____

Answer: propylthiouracil (PTU)

Flashcard 5: _____ is a class III anti-arrhythmic that can produce hyper or hypothyroidism.

Answer: Amiodarone

Flashcard 6: Hypothyroidism may be treated with _____

Answer: thyroid hormone replacement therapy (e.g. levothyroxine, triiodothyronine)

Flashcard 7: Beta Blockers are used to treat _____ by blocking the hyperadrenergic symptoms

Answer: Thyrotoxicosis (thyroid storm)

Flashcard 8: mestranol

Answer: estrogen

Extra: hypognadism, ovarian failure, menstrual abnormalities, HRT in postmenopausal women, androgen-dependent prostate cancerestrogen receptor-positive breast cancer, hx DVTbinds estrogen receptorincreased risk of endometrial cancer, vaginal bleeding in postmenopausal women

Flashcard 9: Clomiphene mechanism of action (MOA)

Answer: SERM

Extra: Uses: Infertility and PCOS Mechanism: Partial agonist at estrogen receptors in hypothalamus; prevents normal feedback inhibition, increasing LH and FSH release which stimulates ovulation. Side effects: Hot flashes, ovarian enlargement, multiple pregnancy, visual disturbances.

Flashcard 10: tamoxifen

Answer: SERM

Extra: ER-positive breast cancerantagonist at estrogen receptor; specific for breast tissue