SGLT-2 inhibitors US Medical PG Flashcards - Medical Study Cards
Master SGLT-2 inhibitors with OnCourse flashcards. These spaced repetition flashcards are designed for medical students preparing for NEET PG, USMLE Step 1, USMLE Step 2, MBBS exams, and other medical licensing examinations.
SGLT-2 inhibitors Flashcard Deck - 10 Cards
Flashcard 1: At which site do SGLT2 inhibitors block reabsorption of glucose? _____
Answer: proximal tubule of the nephron
Flashcard 2: SGLT2 inhibitors are contraindicated in patients with _____ insufficiency
Answer: renal
Flashcard 3: ARBs are used to treat hypertension, proteinuria, HF, or diabetic nephropathy in patients intolerant to _____
Answer: ACE inhibitors
Flashcard 4: Canagliflozin, dapagliflozin, and empagliflozin are all examples of _____ inhibitors
Answer: SGLT2
Flashcard 5: SGLT2 inhibitors may cause increased risk of vaginal _____
Answer: candidiasis (yeast infection)
Flashcard 6: mestranol
Answer: estrogen
Extra: hypognadism, ovarian failure, menstrual abnormalities, HRT in postmenopausal women, androgen-dependent prostate cancerestrogen receptor-positive breast cancer, hx DVTbinds estrogen receptorincreased risk of endometrial cancer, vaginal bleeding in postmenopausal women
Flashcard 7: Clomiphene mechanism of action (MOA)
Answer: SERM
Extra: Uses: Infertility and PCOS
Mechanism: Partial agonist at estrogen receptors in hypothalamus; prevents normal feedback inhibition, increasing LH and FSH release which stimulates ovulation.
Side effects: Hot flashes, ovarian enlargement, multiple pregnancy, visual disturbances.
Flashcard 8: tamoxifen
Answer: SERM
Extra: ER-positive breast cancerantagonist at estrogen receptor; specific for breast tissue
Flashcard 9: raloxifene
Answer: SERM
Extra: Clinical use: Osteoporosis (reduces bone resorption). \nMechanism: Selective Estrogen Receptor Modulator (SERM). Agonist at bone; Antagonist at breast and uterus (no increased risk of endometrial cancer).
Flashcard 10: What are the clinical uses and mechanism of action of progestins?
Answer: Uses: contraception, endometrial cancer, abnormal uterine bleeding.
Mechanism: binds progesterone receptor; reduces proliferation of endometrium, thickens cervical mucus.
Extra: Progestins (e.g., levonorgestrel, medroxyprogesterone) are used to oppose estrogen's effects on the endometrium, reducing the risk of endometrial hyperplasia/cancer. In contraception, they thicken cervical mucus to inhibit sperm penetration and may inhibit ovulation.
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