Growth hormone and analogs — Flashcards

Flashcard 1: Octreotide may cause _____ side effects

Answer: GI

Flashcard 2: What hormone analog may be used to treat VIPoma and carcinoid syndrome?_____

Answer: Octreotide (somatostatin analog)

Flashcard 3: Glucocorticoids may cause _____ due to inhibition of osteoblast activity. Bonus: what supplements should be taken to prevent this?

Answer: Osteoporosis Bonus: Calcium and Vitamin D supplements

Flashcard 4: Ethinyl estradiol, DES, and mestranol are examples _____ analogs

Answer: estrogen

Flashcard 5: A metabolic adverse effect of mecasermin, a recombinant IGF-1, is _____

Answer: hypoglycemia

Flashcard 6: GLP-1 analogs cause increased _____ release and satiety

Answer: insulin

Flashcard 7: mestranol

Answer: estrogen

Extra: hypognadism, ovarian failure, menstrual abnormalities, HRT in postmenopausal women, androgen-dependent prostate cancerestrogen receptor-positive breast cancer, hx DVTbinds estrogen receptorincreased risk of endometrial cancer, vaginal bleeding in postmenopausal women

Flashcard 8: Clomiphene mechanism of action (MOA)

Answer: SERM

Extra: Uses: Infertility and PCOS Mechanism: Partial agonist at estrogen receptors in hypothalamus; prevents normal feedback inhibition, increasing LH and FSH release which stimulates ovulation. Side effects: Hot flashes, ovarian enlargement, multiple pregnancy, visual disturbances.

Flashcard 9: tamoxifen

Answer: SERM

Extra: ER-positive breast cancerantagonist at estrogen receptor; specific for breast tissue

Flashcard 10: raloxifene

Answer: SERM

Extra: Clinical use: Osteoporosis (reduces bone resorption). \nMechanism: Selective Estrogen Receptor Modulator (SERM). Agonist at bone; Antagonist at breast and uterus (no increased risk of endometrial cancer).