Gonadal hormones (estrogens, progestins) — Flashcards

Flashcard 1: What is the mechanism by which progestins, alone, act as a contraceptive? _____

Answer: Thicken cervical mucus

Flashcard 2: Estrogen analogs induce a _____-coaguable state

Answer: hyper

Flashcard 3: Oral _____ contain high doses of estrogen and progesterone (or progesterone alone) which prevent ovulation via inhibition of FSH and LH

Answer: contraceptives

Flashcard 4: Tamoxifen increases the risk of thromboembolic events and _____ cancer

Answer: endometrial

Flashcard 5: What is the effect of oral contraceptives on coagulability? _____

Answer: Increases coagulability

Flashcard 6: What drug class do mifepristone and ulipristal belong to?

Answer: Anti-progestins

Flashcard 7: What drug class do anastrozole and letrozole belong to?_____

Answer: Aromatase inhibitors

Flashcard 8: mestranol

Answer: estrogen

Extra: hypognadism, ovarian failure, menstrual abnormalities, HRT in postmenopausal women, androgen-dependent prostate cancerestrogen receptor-positive breast cancer, hx DVTbinds estrogen receptorincreased risk of endometrial cancer, vaginal bleeding in postmenopausal women

Flashcard 9: Clomiphene mechanism of action (MOA)

Answer: SERM

Extra: Uses: Infertility and PCOS Mechanism: Partial agonist at estrogen receptors in hypothalamus; prevents normal feedback inhibition, increasing LH and FSH release which stimulates ovulation. Side effects: Hot flashes, ovarian enlargement, multiple pregnancy, visual disturbances.

Flashcard 10: tamoxifen

Answer: SERM

Extra: ER-positive breast cancerantagonist at estrogen receptor; specific for breast tissue