GLP-1 receptor agonists US Medical PG Flashcards - Medical Study Cards
Master GLP-1 receptor agonists with OnCourse flashcards. These spaced repetition flashcards are designed for medical students preparing for NEET PG, USMLE Step 1, USMLE Step 2, MBBS exams, and other medical licensing examinations.
GLP-1 receptor agonists Flashcard Deck - 10 Cards
Flashcard 1: Which type(s) of diabetes may be treated with pramlintide (amylin analogs)? _____
Answer: T1DM and T2DM
Flashcard 2: Do GLP-1 agonists and/or DPP-4 inhibitors cause hypoglycemia as a possible side effect?_____
Answer: No
Flashcard 3: GLP-1 agonists can cause _____ as a possible side effect, as well as nausea and vomiting
Answer: pancreatitis
Flashcard 4: Exenatide and liraglutide are both examples of _____
Answer: GLP-1 agonists
Flashcard 5: GLP-1 agonists cause increased satiety via decreased _____
Answer: gastric emptying
Flashcard 6: mestranol
Answer: estrogen
Extra: hypognadism, ovarian failure, menstrual abnormalities, HRT in postmenopausal women, androgen-dependent prostate cancerestrogen receptor-positive breast cancer, hx DVTbinds estrogen receptorincreased risk of endometrial cancer, vaginal bleeding in postmenopausal women
Flashcard 7: Clomiphene mechanism of action (MOA)
Answer: SERM
Extra: Uses: Infertility and PCOS
Mechanism: Partial agonist at estrogen receptors in hypothalamus; prevents normal feedback inhibition, increasing LH and FSH release which stimulates ovulation.
Side effects: Hot flashes, ovarian enlargement, multiple pregnancy, visual disturbances.
Flashcard 8: tamoxifen
Answer: SERM
Extra: ER-positive breast cancerantagonist at estrogen receptor; specific for breast tissue
Flashcard 9: raloxifene
Answer: SERM
Extra: Clinical use: Osteoporosis (reduces bone resorption). \nMechanism: Selective Estrogen Receptor Modulator (SERM). Agonist at bone; Antagonist at breast and uterus (no increased risk of endometrial cancer).
Flashcard 10: What are the clinical uses and mechanism of action of progestins?
Answer: Uses: contraception, endometrial cancer, abnormal uterine bleeding.
Mechanism: binds progesterone receptor; reduces proliferation of endometrium, thickens cervical mucus.
Extra: Progestins (e.g., levonorgestrel, medroxyprogesterone) are used to oppose estrogen's effects on the endometrium, reducing the risk of endometrial hyperplasia/cancer. In contraception, they thicken cervical mucus to inhibit sperm penetration and may inhibit ovulation.
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