Non-opioid analgesics — Flashcards

Flashcard 1: Aspirin inhibits cyclooxygenase via irreversible covalent _____

Answer: acetylation

Flashcard 2: What toxic intermediate is formed in small amounts by metabolism of acetaminophen? _____

Answer: NAPQI

Flashcard 3: What non-volatile acid may be elevated with aspirin overdose? _____

Answer: Salicylic acid

Flashcard 4: Acetaminophen exerts its effects via _____ inhibition of cyclooxygenase (reversible or irreversible)

Answer: reversible

Flashcard 5: NSAIDs can cause _____ nephritis as an adverse effect

Answer: acute interstitial

Flashcard 6: Is acetaminophen useful as an antipyretic and analgesic?_____

Answer: Yes

Flashcard 7: NSAIDs can cause _____ necrosis (kidney) as an adverse effect

Answer: renal papillary

Flashcard 8: Teratogenic effects of Carbamazepine

Answer: Neural tube defects, craniofacial defects, fingernail hypoplasia, developmental delay, IUGR

Flashcard 9: What is the characteristic teratogenic effect associated with Phenytoin use during pregnancy?

Answer: Fetal hydantoin syndrome

Extra: Fetal hydantoin syndrome is characterized by: - Orofacial clefts (cleft lip/palate) - Microcephaly and mental retardation - Nail and digital hypoplasia - Cardiac defects

Flashcard 10: valproate

Answer: neural tube defects (inhibition of maternal folate absorption)