Antiepileptic drug interactions — Flashcards

Flashcard 1: What is the most serious adverse effect associated with lamotrigine use?_____

Answer: Stevens-Johnson syndrome

Flashcard 2: Which anti-epileptic is most associated with drug-induced lupus? _____

Answer: Phenytoin

Flashcard 3: Stevens-Johnson syndrome typically arises as an adverse _____ reaction

Answer: drug

Flashcard 4: NNRTIs have varying effects on _____ and thus may have many drug interactions

Answer: CYP450

Flashcard 5: What teratogenic effect is associated with valproic acid? _____

Answer: Neural tube defects (e.g. spina bifida)

Flashcard 6: Carbamazepine is an _____ of CYP-450

Answer: inducer

Flashcard 7: Isoniazid _____ cytochrome p450 (induces or inhibits)

Answer: inhibits

Flashcard 8: Teratogenic effects of Carbamazepine

Answer: Neural tube defects, craniofacial defects, fingernail hypoplasia, developmental delay, IUGR

Flashcard 9: What is the characteristic teratogenic effect associated with Phenytoin use during pregnancy?

Answer: Fetal hydantoin syndrome

Extra: Fetal hydantoin syndrome is characterized by: - Orofacial clefts (cleft lip/palate) - Microcephaly and mental retardation - Nail and digital hypoplasia - Cardiac defects

Flashcard 10: valproate

Answer: neural tube defects (inhibition of maternal folate absorption)