Adjuvant analgesics — Flashcards

Flashcard 1: SNRIs may be used to treat chronic pain (e.g. _____ pain)

Answer: neuropathic

Flashcard 2: TCAs may be used to treat peripheral neuropathy and chronic pain (e.g. _____ pain)

Answer: neuropathic

Flashcard 3: Carbamazepine is a _____ spectrum anti-epileptic

Answer: narrow

Flashcard 4: Ketamine causes cardiovascular _____ (depression or stimulation)

Answer: stimulation

Flashcard 5: Ketamine (an arylcyclohexylamine) is a PCP analog that causes '_____ anesthesia'

Answer: dissociative

Flashcard 6: What classes (2) of antidepressant are useful for treating fibromyalgia? _____

Answer: TCAs and SNRIs

Flashcard 7: Teratogenic effects of Carbamazepine

Answer: Neural tube defects, craniofacial defects, fingernail hypoplasia, developmental delay, IUGR

Flashcard 8: What is the characteristic teratogenic effect associated with Phenytoin use during pregnancy?

Answer: Fetal hydantoin syndrome

Extra: Fetal hydantoin syndrome is characterized by: - Orofacial clefts (cleft lip/palate) - Microcephaly and mental retardation - Nail and digital hypoplasia - Cardiac defects

Flashcard 9: valproate

Answer: neural tube defects (inhibition of maternal folate absorption)

Flashcard 10: Mechanism and use of Levodopa?

Answer: Dopamine precursor used in Parkinson's disease

Extra: Mechanism: Crosses blood-brain barrier (BBB) and is converted to dopamine by dopa decarboxylase. Clinical Use: Parkinson's disease. Side effects: GI distress, nausea, arrhythmias, dyskinesia (on-dose), akinesia (wearing-off/between dose).