Topoisomerase inhibitors — Flashcards

Flashcard 1: Which Topoisomerases do Fluoroquinolones inhibit?_____

Answer: II and IV

Flashcard 2: Which enzyme is inhibited by teniposide?_____

Answer: topoisomerase II

Flashcard 3: Which enzyme is inhibited by topotecan?_____

Answer: topoisomerase I

Flashcard 4: Irinotecan and topotecan can result in _____-suppression

Answer: myelo

Flashcard 5: Which topoisomerase I inhibitor is indicated in ovarian and small cell lung cancer?_____

Answer: topotecan

Flashcard 6: Which enzyme is inhibited by etoposide?_____

Answer: topoisomerase II

Flashcard 7: anastrazole

Answer:

Extra: breast cancer in postmenopausal womenaromatase inhibitor

Flashcard 8: exemestane

Answer:

Extra: breast cancer in postmenopausal womenaromatase inhibitor

Flashcard 9: alkylating agents

Answer: absence of digits (and multiple varied anomalies)

Flashcard 10: folate antagonists

Answer: neural tube defects