Peripheral nerve disorders — Flashcards

Flashcard 1: Nephritic syndrome occurs due to _____ disruption

Answer: GBM

Flashcard 2: Diabetic glomerulonephropathy is associated with _____ proliferation on light microscopy

Answer: mesangial

Flashcard 3: _____ is a trinucleotide repeat disorder that causes degeneration of the cerebellum and multiple spinal cord tracts

Answer: Friedreich ataxia

Flashcard 4: Tabes Dorsalis is characterized by _____ joints due to loss of proprioception

Answer: charcot

Flashcard 5: Histologically, patients with diabetic neuropathy will have endoneural arteriole _____

Answer: hyalinization

Flashcard 6: Which nervous system cell is typically damaged by Guillain-Barre syndrome? _____

Answer: Schwann cells

Flashcard 7: What lysosomal storage disease presents with central and peripheral demyelination with ataxia and dementia?_____

Answer: Metachromatic leukodystrophy

Flashcard 8: Niemann-Pick disease

Answer:

Extra: accumulation of sphingomyelinprogressive neurodegeneration, hepatosplenomegaly, cherry-red spot on macula foam cells Ashkenazi JewAR sphingomyelinase 

Flashcard 9: Gaucher's disease

Answer:

Extra: accumulation of glucocerebrosidehepatosplenomegaly, aseptic necrosis of femur, bone crisescrumpled-paper cells Ashkenazi JewARglucocerebrosidase

Flashcard 10: Patau's syndrome

Answer:

Extra: severe mental retardation, rocker-bottom feet, microopthalmia, microcephaly, cleft lip/palate, polydactyly, holoprosencephalyfirst trimester pregnancy screen: decreased - β-hCG, PAPP-A ultrasound: increased nuchal translucency in first trimesterdeath within first yeartrisomy 13