Metastatic CNS tumors — Flashcards

Flashcard 1: Oligodendroglioma may present with _____

Answer: seizures

Flashcard 2: When performing Immunohistochemistry; a _____ stain can be used to identify Astrocytomas, Glioblastomas, Oligodendrogliomas, Ependymomas

Answer: Glial Fibrillary Acidic Protein (GFAP)

Flashcard 3: Which CNS tumor is characterized histologically by "pseudopalisading" necrosis?

Answer: Glioblastoma multiforme (GBM)

Flashcard 4: Does metastasis to the lung typically present as single or multiple lesions? _____

Answer: Multiple

Flashcard 5: Infarction and/or neoplasm of the blood-brain-barrier destroys endothelial cell tight junctions, causing _____

Answer: vasogenic edema

Flashcard 6: What is the most common primary malignant CNS tumor in adults? _____

Answer: Glioblastoma multiforme (GBM)

Flashcard 7: Do primary malignant CNS tumors typically metastasize? _____

Answer: No

Flashcard 8: The CNS tumor that is histologically identical to testicular seminoma and ovarian dysgerminoma is the _____.

Answer: Germinoma

Extra: Germinomas are the most common tumors of the pineal gland and are histologically identical to testicular seminoma and ovarian dysgerminoma. They characteristically present with Parinaud syndrome (vertical gaze palsy) due to compression of the tectal plate.

Flashcard 9: Metastasis of medulloblastomas to the _____ is termed "drop metastasis"

Answer: spinal cord

Flashcard 10: What is the term for infarcted tissue in the basal ganglia or internal capsule caused by occlusion of a lenticulostriate artery?

Answer: lacunar infarct