Demyelinating diseases — Flashcards

Flashcard 1: Residual chronic findings of multiple sclerosis include hypertrophy and hyperplasia of _____

Answer: astrocytes

Flashcard 2: Multiple sclerosis is characterized histologically by _____ inflammatory infiltrates

Answer: perivenular

Flashcard 3: Nephritic syndrome occurs due to _____ disruption

Answer: GBM

Flashcard 4: Multiple sclerosis is characterized by increased levels of _____ protein in the CSF

Answer: myelin basic

Flashcard 5: Alzheimer disease is characterized histologically by _____ plaques in gray matter

Answer: neuritic (senile)

Flashcard 6: The neuritic plaques seen in Alzheimer's are composed of _____ with entangled neuritic processes

Answer: Aβ amyloid (Amyloid-beta)

Flashcard 7: Which peripheral nerve layer contains inflammatory infiltrate in Guillain-Barre syndrome? _____

Answer: Endoneurium

Flashcard 8: What lysosomal storage disease presents with central and peripheral demyelination with ataxia and dementia?_____

Answer: Metachromatic leukodystrophy

Flashcard 9: What is the term for infarcted tissue in the basal ganglia or internal capsule caused by occlusion of a lenticulostriate artery?

Answer: lacunar infarct

Flashcard 10: epidural hematoma

Answer: rupture of middle meningeal artery; fracture of temporal bone

Extra: rapid arterial bleedinglucid interval followed by decreased LOC; CN 3 palsy, increased ICPCT: biconvex, hyperdense blood; does not cross sutures; may cross falx, tentorium