Transplant rejection mechanisms — Flashcards

Flashcard 1: What type of hypersensitivity is acute hemolytic transfusion reaction?_____

Answer: Type II HSR

Flashcard 2: Which MHC class is associated with the gene products of HLA-A, HLA-B, and HLA-C? _____

Answer: MHC I

Flashcard 3: What type of hypersensitivity reaction is type I diabetes mellitus? _____

Answer: Type IV HSR (direct cell cytotoxicity)

Flashcard 4: What type of cast may be seen with transplant rejection and tubulointerstitial inflammation? _____

Answer: WBC casts

Flashcard 5: What HLA subtype is associated with psoriasis?_____

Answer: HLA-C

Flashcard 6: What type of hypersensitivity reaction is graft-versus-host-disease? _____

Answer: Type IV HSR (delayed-type hypersensitivity)

Flashcard 7: What type of hypersensitivity reaction is Acute Rheumatic Fever?

Answer: Type 2 hypersensitivity, post S. pyogenes infection (Molecular mimicry)

Extra: Major Jones Criteria: Joint (Polyarthritis), ❤️ (Carditis), Nodules (Subcutaneous), Erythema marginatum, Sydenham chorea. \n\nNote: Post-streptococcal glomerulonephritis (PSGN) is Type 3, but Acute Rheumatic Fever is Type 2.