Systemic autoimmune diseases — Flashcards

Flashcard 1: What MSK pathology is characterized by a reduction in trabecular and cortical bone mass and interconnections? _____

Answer: Osteoporosis

Flashcard 2: What type of amyloidosis is associated with rheumatoid arthritis?_____

Answer: Secondary (AA) amyloidosis

Flashcard 3: Myasthenia Gravis is a paraneoplastic syndrome associated with _____

Answer: Thymoma

Flashcard 4: The PD1 receptor is normally involved in the maintainance of _____ immunologic tolerance

Answer: peripheral

Flashcard 5: Nephrotic syndrome may be caused by systemic _____

Answer: amyloidosis

Flashcard 6: What immunofluorescence findings are associated with minimal change disease? _____

Answer: None (no immune complex deposits)

Flashcard 7: The dermatitis herpetiformis that arises with celiac disease is due to _____ deposition at the tips of the dermal papillae

Answer: IgA

Flashcard 8: What type of hypersensitivity reaction is Acute Rheumatic Fever?

Answer: Type 2 hypersensitivity, post S. pyogenes infection (Molecular mimicry)

Extra: Major Jones Criteria: Joint (Polyarthritis), ❤️ (Carditis), Nodules (Subcutaneous), Erythema marginatum, Sydenham chorea. \n\nNote: Post-streptococcal glomerulonephritis (PSGN) is Type 3, but Acute Rheumatic Fever is Type 2.