Secondary immunodeficiencies — Flashcards

Flashcard 1: What laboratory technique is useful in determining CD4 cell count in HIV patients? _____

Answer: Flow cytometry

Flashcard 2: HIV-associated dementia can result in activation of _____ cells that form nodules

Answer: microglial

Flashcard 3: Which immunodeficiency is associated with an infiltrative lymphohistiocytosis?_____

Answer: Chediak-Higashi

Flashcard 4: Which subtype of Hodgkin lymphoma is usually seen (strongest association) in the elderly and HIV+ individuals? _____

Answer: Lymphocyte-depleted

Flashcard 5: Which immunodeficiency is caused by failure to repair DNA double strand breaks? _____

Answer: Ataxia-telangiectasia

Flashcard 6: Myeloperoxidase deficiency is associated with increased risk for _____ infection, however, most patients are asymptomatic

Answer: Candida

Flashcard 7: What type of hypersensitivity reaction is Acute Rheumatic Fever?

Answer: Type 2 hypersensitivity, post S. pyogenes infection (Molecular mimicry)

Extra: Major Jones Criteria: Joint (Polyarthritis), ❤️ (Carditis), Nodules (Subcutaneous), Erythema marginatum, Sydenham chorea. \n\nNote: Post-streptococcal glomerulonephritis (PSGN) is Type 3, but Acute Rheumatic Fever is Type 2.