Autoimmune mechanisms — Flashcards

Flashcard 1: SCID may be caused by MHC class _____ deficiency

Answer: II

Flashcard 2: What type of hypersensitivity reaction is chronic autoimmune gastritis? _____

Answer: Type IV (T-cell mediated)

Flashcard 3: The PD1 receptor is normally involved in the maintainance of _____ immunologic tolerance

Answer: peripheral

Flashcard 4: What type of hypersensitivity reaction is Sjogren syndrome? _____

Answer: Type IV (lymphocyte-mediated damage)

Flashcard 5: What type of hypersensitivity is type 1 DM? _____

Answer: type IV HSR

Flashcard 6: Pathogenesis of asthma involves allergens inducing a TH_____ phenotype in CD4+ T cells of genetically susceptible individuals

Answer: 2

Flashcard 7: What HLA subtype is associated with hay fever? _____

Answer: DR2

Flashcard 8: _____ refers to a state in which an immune cell cannot become activated by exposure to its antigen

Answer: Anergy

Flashcard 9: What type of hypersensitivity reaction is Acute Rheumatic Fever?

Answer: Type 2 hypersensitivity, post S. pyogenes infection (Molecular mimicry)

Extra: Major Jones Criteria: Joint (Polyarthritis), ❤️ (Carditis), Nodules (Subcutaneous), Erythema marginatum, Sydenham chorea. \n\nNote: Post-streptococcal glomerulonephritis (PSGN) is Type 3, but Acute Rheumatic Fever is Type 2.