White blood cell disorders — Flashcards

Flashcard 1: The t(9;22) translocation (BCR-ABL) is also known as the _____ chromosome

Answer: Philadelphia

Flashcard 2: Chronic myeloproliferative disorders (except CML) are associated with _____ mutations

Answer: V617F JAK2

Flashcard 3: A leukemoid reaction is a severe elevation in WBC, typically >_____ cells/mm3

Answer: 50,000

Flashcard 4: Is chronic myeloid leukemia associated with JAK2 mutations?_____

Answer: No (associated with Philadelphia chromosome)

Flashcard 5: Positive TRAP stain for diagnosis of hairy cell leukemia has been largely replaced with _____

Answer: flow cytometry

Flashcard 6: Leukocyte adhesion deficiency is characterized by _____ circulating neutrophils

Answer: increased

Flashcard 7: Multiple myeloma is associated with _____ of RBCs on blood smear

Answer: Rouleaux formation

Flashcard 8: _____ leukemia (acute or chronic) is a neoplastic proliferation of mature circulating lymphocytes

Answer: Chronic

Flashcard 9: A _____ shift is an increase in neutrophil precursors, such as band cells and metamyelocytes, in peripheral blood

Answer: left

Flashcard 10: Most common type of testicular lymphoma?

Answer: Diffuse Large B-cell Lymphoma (DLBCL) is the most common; often represents dissemination from an occult primary site.

Extra: - Most common testicular tumor in men aged >60.\n- Highly aggressive; prognosis is generally poor.\n- Bilateral involvement is common (most common bilateral testicular tumor).