Myeloproliferative neoplasms — Flashcards

Flashcard 1: The t(9;22) translocation (BCR-ABL) is also known as the _____ chromosome

Answer: Philadelphia

Flashcard 2: Is essential thrombocythemia (ET) associated with JAK2 mutations? What other mutations are commonly involved?

Answer: Yes (~50-60%). It is also associated with **CALR** (calreticulin) and **MPL** mutations.

Extra: Approximately 10-15% of patients with Essential Thrombocythemia are "triple-negative," meaning they lack JAK2, CALR, and MPL mutations.

Flashcard 3: Is Primary Myelofibrosis associated with JAK2 mutations?

Answer: Yes (approximately 50-60% of cases)

Flashcard 4: Gain of functions in the _____ oncogene result in chronic myeloproliferative disorders

Answer: JAK2

Flashcard 5: Chronic myeloproliferative disorders (except CML) are associated with _____ mutations

Answer: V617F JAK2

Flashcard 6: Mutations in which proto-oncogene can lead to Chronic Myeloproliferative Disorders?_____

Answer: JAK2

Flashcard 7: Most common type of testicular lymphoma?

Answer: Diffuse Large B-cell Lymphoma (DLBCL) is the most common; often represents dissemination from an occult primary site.

Extra: - Most common testicular tumor in men aged >60.\n- Highly aggressive; prognosis is generally poor.\n- Bilateral involvement is common (most common bilateral testicular tumor).

Flashcard 8: What kinds of tissue samples can be used for karyotyping?

Answer: blood, bone marrow, amniotic fluid, placental tissue